DKK2 Protein (His tag)
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- Target See all DKK2 Proteins
- DKK2 (Dickkopf 2 Homolog (DKK2))
- Protein Type
- Recombinant
- Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This DKK2 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Purity
- > 90 % by SDS - PAGE
- Top Product
- Discover our top product DKK2 Protein
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- Comment
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Synonyms: Dickkopf-related protein 2, DKK-2
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.25 mg/ml (determined by Bradford assay)
- Buffer
- 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M urea, 10% glycerol
- Storage
- 4 °C
- Storage Comment
- Avoid repeated freezing and thawing cycles.
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- Target
- DKK2 (Dickkopf 2 Homolog (DKK2))
- Alternative Name
- DKK2 (DKK2 Products)
- Synonyms
- DKK-2 Protein, Dkk4 Protein, zgc:171574 Protein, dickkopf WNT signaling pathway inhibitor 2 Protein, DKK2 Protein, Dkk2 Protein, dkk2 Protein
- Background
- Dickkopf-related protein 2, also known as DKK2, belongs to the dickkopf family. DKK2 antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Recombinant human DKK2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
- Molecular Weight
- 27.6 kDa (250aa)
- NCBI Accession
- NP_055236
- Pathways
- WNT Signaling
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