Coxsackie Adenovirus Receptor Protein (AA 20-237) (His tag)

Catalog No. ABIN2180951

Product Details

Target: Coxsackie Adenovirus Receptor (CXADR) (Coxsackie Virus and Adenovirus Receptor (CXADR))

Protein Type: Recombinant

Protein Characteristics: AA 20-237

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This Coxsackie Adenovirus Receptor protein is labelled with His tag.

Sequence: AA 20-237

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 24.9 kDa. The protein migrates as 35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: >95 % as determined by SDS-PAGE.

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1.0 EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Handling Advice: Please avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).

Target Details

Target: Coxsackie Adenovirus Receptor (CXADR) (Coxsackie Virus and Adenovirus Receptor (CXADR))

Alternative Name: CXADR (CXADR Products)

Synonyms: CAR Protein, CAR4/6 Protein, HCAR Protein, Car1 Protein, car Protein, cb331 Protein, fb76g12 Protein, wu:fb76g12 Protein, 2610206D03Rik Protein, AU016810 Protein, AW553441 Protein, MCAR Protein, MCVADR Protein, hcar Protein, xCAR Protein, CXADR Protein, CXADR, Ig-like cell adhesion molecule Protein, coxsackie virus and adenovirus receptor Protein, CXADR, Ig-like cell adhesion molecule L homeolog Protein, CXADR Protein, Cxadr Protein, cxadr Protein, cxadr.L Protein

Background: Coxsackie virus and adenovirus receptor (CXADR) is also known as CAR, is a type I transmembrane glycoprotein for group B coxsackie viruses and subgroup C adenoviruses, and belongs to the CTX family of the Ig superfamily. CAR is strongly expressed in the developing central nervous system. It functions as a homophilic and also as a heterophilic cell adhesion molecule through its interactions with extracellular matrix glycoproteins such as: fibronectin, agrin, laminin-1 and tenascin-R. Human CXADR protein contains a signal sequence, a extracellular domain (ECD) with a V- type (D1) and a C2- type (D2) Ig-like domain, a  transmembrane segment and a intracellular domain. D1 is thought to be responsible for homodimer formation in trans within tight junctions, and is necessary and sufficient for adenovirus binding. Variants of CXADR are attached to the cell membrane by a GPI- anchor.

Molecular Weight: 24.9 kDa

NCBI Accession: NP_001329

Pathways: Cell-Cell Junction Organization