Coxsackie Adenovirus Receptor Protein (His tag,AVI tag)

Catalog No. ABIN7320866

Product Details

Target: Coxsackie Adenovirus Receptor (CXADR) (Coxsackie Virus and Adenovirus Receptor (CXADR))

Protein Type: Recombinant

Origin: Mouse

Source: Human Cells

Purification tag / Conjugate: This Coxsackie Adenovirus Receptor protein is labelled with His tag,AVI tag.

Purpose: Recombinant Mouse CXADR/CAR Protein (AVI & His Tag)

Sequence: Leu20-Gly237

Characteristics: Biotinylated Recombinant Mouse CXADR is produced by our Mammalian expression system and the target gene encoding Leu20-Gly237 is expressed with a Avi, 6Histag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Coxsackie Adenovirus Receptor (CXADR) (Coxsackie Virus and Adenovirus Receptor (CXADR))

Alternative Name: CXADR/CAR (CXADR Products)

Synonyms: CAR Protein, CAR4/6 Protein, HCAR Protein, Car1 Protein, car Protein, cb331 Protein, fb76g12 Protein, wu:fb76g12 Protein, 2610206D03Rik Protein, AU016810 Protein, AW553441 Protein, MCAR Protein, MCVADR Protein, hcar Protein, xCAR Protein, CXADR Protein, CXADR, Ig-like cell adhesion molecule Protein, coxsackie virus and adenovirus receptor Protein, CXADR, Ig-like cell adhesion molecule L homeolog Protein, CXADR Protein, Cxadr Protein, cxadr Protein, cxadr.L Protein

Background:

Background: Coxsackievirus and adenovirus receptor homolog(CAR), also known as CXADR, is a type I transmembrane glycoprotein that belongs to the CTX family of the Ig superfamily. CXADR has monomer subunit that interacts with LNX, BAIAP1, DLG4, PRKCABP, TJP1 and CTNNB1. It also interacts with MPDZ and JAML. CXADR composed of of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. CXADR also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.

Synonym: Coxsackievirus and adenovirus receptor homolog,CAR,Cxadr,CVB3 BP,MCVADR

Molecular Weight: 26.7 kDa

UniProt: P97792

Pathways: Cell-Cell Junction Organization