Carcinoembryonic Antigen Gene Family (CEA) Protein

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Protein Name
  • CEA
  • CEB
  • Ctsea
  • PSBG2
  • PSG1
  • carcinoembryonic antigen gene family
  • cathepsin E
  • pregnancy specific beta-1-glycoprotein 2
  • Cea
  • Ctse
  • PSG2
Origin
Human
40
4
1
Source
Human
28
11
1
1
Protein Type
Native
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Characteristics Purified native Human CEA protein
Protein Source: Purified human colon carcinoma
Purification Immunoaffinity column
Purity > 98 % pure
Background Carcinoembryonic antigen (CEA) is a glycoprotein involved in cell adhesion. It is normally produced during fetal development, but the production of CEA stops before birth. Therefore, it is not usually present in the blood of healthy adults, although levels are raised in heavy smokers. CEA is a glycosyl phosphatidyl inositol (GPI)-cell surface anchored glycoprotein whose specialized sialofucosylated glycoforms serve as functional colon carcinoma L-selectin and E-selectin ligands, which may be critical to the metastatic dissemination of colon carcinoma cells.
Description: Purified human colon carcinoma.
Alternative Names: Carcinoembryonic Antigen protein
Research Area Cancer
Application Notes Each Investigator should determine their own optimal working dilution for specific applications.
Restrictions For Research Use only
Format Liquid
Buffer Supplied as a liquid in 10 mM PBS, pH 7.5, with 0.1 % NaN3.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid repeated freeze/thaw cycles.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Product cited in: Lima, Jenkins, Guerrero, Triozzi, Shaw, Strong: "A DNA vaccine encoding genetic fusions of carcinoembryonic antigen (CEA) and granulocyte/macrophage colony-stimulating factor (GM-CSF)." in: Vaccine, Vol. 23, Issue 10, pp. 1273-83, 2005 (PubMed).