AOC3 Protein (AA 27-763)
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- Target See all AOC3 Proteins
- AOC3 (Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 27-763
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Application
- Multiplex Assay (MA)
- Purity
- >98 % , as determined by Coomassie stained SDS-PAGE.
- Endotoxin Level
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Less than 0.1 ng per μg of protein.
- Top Product
- Discover our top product AOC3 Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Biological activity: Human VAP-1 is able to produce hydrogen peroxide during the oxidation of benzylamine. The specific activity is > 16 pMoles/min/μg of VAP-1.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- For maximum results, quick spin vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. It is recommended to further dilute in a buffer containing a carrier protein such as 0.1 % BSA and store working aliquots at -20 °C to -80 °C.
- Buffer
- Lyophilized
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- -20 °C
- Storage Comment
- Unopened vial can be stored at -20°C or -70°C.
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- Target
- AOC3 (Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1) (AOC3))
- Alternative Name
- VAP-1 (AOC3 Products)
- Synonyms
- HPAO Protein, SSAO Protein, VAP-1 Protein, VAP1 Protein, aoc2 Protein, BOLAO Protein, amine oxidase, copper containing 3 Protein, amine oxidase, copper containing 3 L homeolog Protein, AOC3 Protein, aoc3.L Protein, Aoc3 Protein
- Background
- VAP-1 is a type II cell adhesion membrane protein belonging to the copper/topaquinone oxidase family. Functionally, VAP-1 is a nonclassical inflammation-inducible endothelial molecule involved in leukocyte-subtype-specific rolling under physiological shear. Molecularly, VAP-1 belongs to a special class of cell surface amino oxidases. The enzymatic reaction itself and the biologically active end products can potentially regulate the adhesive status of the vessel wall. Thus, VAP-1 is an ectoenzyme that has inter-related adhesive and enzymatic functions in regulating physiological trafficking and inflammation. Inhibition of VAP-1 can protect against inflammation related damage to certain injured tissues. This protein is primarily expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Additionally, VAP-1 can function as a significant prognostic marker for certain cancers and cardiovascular diseases.
- Molecular Weight
- The 737 amino acid recombinant protein has a predicted molecular mass of approximately 84 kDa. Recombinant VAP-1 is a mixture of monomers and disulfide linked homodimers. The predicted N-terminal amino acid is Gly.
- Pathways
- Feeding Behaviour
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