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Calpain 2 Protein (CAPN2) (Myc-DYKDDDDK Tag)

CAPN2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2713061
  • Target See all Calpain 2 (CAPN2) Proteins
    Calpain 2 (CAPN2)
    Protein Type
    Recombinant
    Origin
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Source
    • 4
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This Calpain 2 protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human Calpain-2 protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product CAPN2 Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Pan, Zhou, Mahsut, Rohm, Berejnaia, Price, Chen, Castro-Perez, Lassman, McLaren, Conway, Jensen, Thomas, Reyes-Soffer, Ginsberg, Gutstein, Cleary, Previs, Roddy: "Static and turnover kinetic measurement of protein biomarkers involved in triglyceride metabolism including apoB48 and apoA5 by LC/MS/MS." in: Journal of lipid research, Vol. 55, Issue 6, pp. 1179-87, (2016) (PubMed).

    Miyaji, Shahrizaila, Umapathi, Chan, Hirata, Yuki: "Are ERM (ezrin/radixin/moesin) proteins targets for autoantibodies in demyelinating neuropathies?" in: Human immunology, Vol. 75, Issue 11, pp. 1089-91, (2015) (PubMed).

    Oh, Choung, Lee, Park, Lee, Lee, Seo, Park: "CPNE7, a preameloblast-derived factor, regulates odontoblastic differentiation of mesenchymal stem cells." in: Biomaterials, Vol. 37, pp. 208-17, (2015) (PubMed).

    Adini, Adini, Bazinet, Watnick, Bielenberg, DAmato: "Melanocyte pigmentation inversely correlates with MCP-1 production and angiogenesis-inducing potential." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, (2014) (PubMed).

    Boxer, Barajas, Tao, Zhang, Khavari: "ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes." in: Genes & development, Vol. 28, Issue 18, pp. 2013-26, (2014) (PubMed).

    Briz, Hsu, Li, Lee, Bi, Baudry: "Calpain-2-mediated PTEN degradation contributes to BDNF-induced stimulation of dendritic protein synthesis." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 10, pp. 4317-28, (2013) (PubMed).

    Wang, Briz, Chishti, Bi, Baudry: "Distinct roles for μ-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 48, pp. 18880-92, (2013) (PubMed).

    Ye, Gao, Tian, Yearsley, Lange, Robertson, Barsky: "Early to intermediate steps of tumor embolic formation involve specific proteolytic processing of E-cadherin regulated by Rab7." in: Molecular cancer research : MCR, Vol. 10, Issue 6, pp. 713-26, (2012) (PubMed).

    Lin, Wu, Dong, Bouck, Zeng, Chen: "Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells." in: The Journal of biological chemistry, Vol. 283, Issue 45, pp. 30650-7, (2008) (PubMed).

  • Target
    Calpain 2 (CAPN2)
    Alternative Name
    Calpain-2 (CAPN2 Products)
    Synonyms
    CANP2 Protein, CANPL2 Protein, CANPml Protein, mCANP Protein, AI326419 Protein, Capa-2 Protein, Capa2 Protein, m-calpain Protein, m-calpin Protein, capn2 Protein, CAPN2 Protein, im:6908877 Protein, zgc:109906 Protein, calpain 2 Protein, calpain 2, gene2 Protein, calpain 2, (m/II) large subunit b Protein, CAPN2 Protein, Capn2 Protein, capn2.2 Protein, capn2b Protein
    Background
    The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene.
    Molecular Weight
    79.8 kDa
    NCBI Accession
    NP_001739
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