LSD1 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2714763

Product Details

Target: LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 1

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This LSD1 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human AOF2 (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

References

Boxer, Barajas, Tao, Zhang, Khavari: "ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes." in: Genes & development, Vol. 28, Issue 18, pp. 2013-26, (2014) (PubMed).

Target Details

Target: LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))

Alternative Name: Aof2 (KDM1A Products)

Synonyms: AOF2 Protein, BHC110 Protein, KDM1 Protein, LSD1 Protein, 1810043O07Rik Protein, AA408884 Protein, Aof2 Protein, D4Ertd478e Protein, Kdm1 Protein, Lsd1 Protein, mKIAA0601 Protein, DKFZp459N2450 Protein, RGD1562975 Protein, aof2 Protein, kdm1 Protein, wu:fb82e06 Protein, wu:fc51a02 Protein, wu:fj36a05 Protein, wu:fj66b06 Protein, KDM1A Protein, lsd1 Protein, xLSD1 Protein, AtLSD1 Protein, F9F13.30 Protein, F9F13_30 Protein, LESION SIMULATING DISEASE Protein, LESION SIMULATING DISEASE 1 Protein, lysine demethylase 1A Protein, lysine (K)-specific demethylase 1A Protein, lysine (K)-specific demethylase 1a Protein, LSD1 zinc finger family protein Protein, KDM1A Protein, Kdm1a Protein, kdm1a Protein, LSD1 Protein

Background: This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants.

Molecular Weight: 95.6

NCBI Accession: NP_001009999

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Negative Regulation of intrinsic apoptotic Signaling, Warburg Effect