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GDF7 Protein

GDF7 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, Func, PI, STD Active
Catalog No. ABIN2715290
  • Target See all GDF7 Proteins
    GDF7 (Growth Differentiation Factor 7 (GDF7))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Origin
    • 4
    • 3
    • 1
    • 1
    Human
    Source
    • 4
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Application
    Antibody Production (AbP), Functional Studies (Func), Protein Interaction (PI), Standard (STD)
    Specificity
    Optimal preservation of protein structure, post-translational modifications and functions.
    Characteristics
    • Recombinant human BMP12 / GDF7 protein expressed in E. coli.
    • Produced with end-sequenced ORF clone
    • Tested for bioactivity.
    Purity
    > 95 % as determined by SDS-PAGE and Coomassie blue staining
    Endotoxin Level
    Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).
    Biological Activity Comment
    Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells.
    Top Product
    Discover our top product GDF7 Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Protein-protein interaction
    In vitro biochemical assays and cell-based functional assays
    Restrictions
    For Research Use only
  • Buffer
    Lyophilized from a 0.2 μM filtered solution of 20 mM phosphate buffer,100 mM NaCl, pH 7.2
    Handling Advice
    Resuspend the protein in the desired concentration in proper buffer
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    GDF7 (Growth Differentiation Factor 7 (GDF7))
    Alternative Name
    Bmp12,gdf7 (GDF7 Products)
    Synonyms
    bmp12 Protein, gdf-7 Protein, gdf16 Protein, gdf16-A Protein, BMP12 Protein, GDF6/7 Protein, growth differentiation factor 7 S homeolog Protein, growth differentiation factor 7 Protein, gdf7.S Protein, GDF7 Protein, Gdf7 Protein
    Background
    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma.
    Molecular Weight
    28 kDa
    NCBI Accession
    NP_878248
    Pathways
    Tube Formation
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