GDF6 Protein
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- Target See all GDF6 Proteins
- GDF6 (Growth Differentiation Factor 6 (GDF6))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Application
- Antibody Production (AbP), Functional Studies (Func), Protein Interaction (PI), Standard (STD)
- Specificity
- Optimal preservation of protein structure, post-translational modifications and functions.
- Characteristics
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- Recombinant human BMP13 / GDF6 protein expressed in E. coli.
- Produced with end-sequenced ORF clone
- Tested for bioactivity.
- Purity
- > 95 % as determined by SDS-PAGE and Coomassie blue staining
- Endotoxin Level
- Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).
- Biological Activity Comment
- ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells in the range of 2.0-3.0 ug/ml.
- Top Product
- Discover our top product GDF6 Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays
Protein-protein interaction
In vitro biochemical assays and cell-based functional assays - Restrictions
- For Research Use only
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- Buffer
- Lyophilized from a 0.2 μM filtered solution of 20 mM phosphate buffer,100 mM NaCl, pH 7.2
- Handling Advice
- Resuspend the protein in the desired concentration in proper buffer
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- GDF6 (Growth Differentiation Factor 6 (GDF6))
- Alternative Name
- Bmp13,gdf6 (GDF6 Products)
- Synonyms
- BMP13 Protein, CDMP2 Protein, KFM Protein, KFS Protein, KFS1 Protein, KFSL Protein, LCA17 Protein, MCOP4 Protein, MCOPCB6 Protein, SCDO4 Protein, SGM1 Protein, GDF16 Protein, gdf16 Protein, CDMP-2 Protein, gdf6 Protein, rdr Protein, sb:cb278 Protein, bmp13 Protein, cdmp2 Protein, gdf-6 Protein, kfs Protein, kfsl Protein, sgm1 Protein, growth differentiation factor 6 Protein, growth differentiation factor 6a Protein, growth differentiation factor 6 S homeolog Protein, GDF6 Protein, Gdf6 Protein, gdf6 Protein, gdf6a Protein, gdf6.S Protein
- Background
- This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene are associated with Klippel-Feil syndrome, microphthalmia, and Leber congenital amaurosis.
- Molecular Weight
- 27 kDa
- NCBI Accession
- NP_001001557
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