KMO Protein (Myc-DYKDDDDK Tag)
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- Target See all KMO Proteins
- KMO (Kynurenine 3-Monooxygenase (Kynurenine 3-Hydroxylase) (KMO))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This KMO protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human Kynurenine 3-monooxygenase / KMO (N-term AVI tag, C-term MYC/DDK tag) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product KMO Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris-HCl, pH 7.3, 100 mM glycine, 10 % glycerol. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- KMO (Kynurenine 3-Monooxygenase (Kynurenine 3-Hydroxylase) (KMO))
- Alternative Name
- Kynurenine 3-Monooxygenase,kmo (KMO Products)
- Synonyms
- AI046660 Protein, dJ317G22.1 Protein, kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Protein, kynurenine 3-monooxygenase Protein, Kmo Protein, KMO Protein
- Background
- Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. [UniProtKB/Swiss-Prot Function]
- Molecular Weight
- 61.6 kDa
- NCBI Accession
- NP_003670
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