MRVI1 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)
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- Target See all MRVI1 Proteins
- MRVI1 (Murine Retrovirus Integration Site 1 Homolog (MRVI1))
- Protein Type
- Recombinant
- Protein Characteristics
- Transcript Variant 1
- Origin
- Human
- Source
- HEK-293 Cells
- Purification tag / Conjugate
- This MRVI1 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human MRVI1 / IRAG (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- MRVI1 (Murine Retrovirus Integration Site 1 Homolog (MRVI1))
- Alternative Name
- Mrvi1,irag (MRVI1 Products)
- Synonyms
- BB115629 Protein, Irag Protein, Ris1 Protein, IRAG Protein, JAW1L Protein, MRV integration site 1 Protein, murine retrovirus integration site 1 homolog Protein, Mrvi1 Protein, MRVI1 Protein
- Background
- This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used.
- Molecular Weight
- 97.7 kDa
- NCBI Accession
- NP_001092049
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