NSMCE2 Protein (His tag)
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- Target See all NSMCE2 Proteins
- NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This NSMCE2 protein is labelled with His tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human NSMCE2 (full length, N-term HIS tag) protein expressed in E.coli.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product NSMCE2 Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the N-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))
- Alternative Name
- Nsmce2 (NSMCE2 Products)
- Synonyms
- 1110014D18Rik Protein, AI661537 Protein, RGD1305156 Protein, C8orf36 Protein, MMS21 Protein, NSE2 Protein, ZMIZ7 Protein, Non-SMC element 2 Protein, NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase Protein, NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase L homeolog Protein, Smc5-6 complex non-SMC subunit 2 Protein, Nsmce2 Protein, NSMCE2 Protein, nsmce2.L Protein, nse2 Protein
- Background
- This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance.
- Molecular Weight
- 27.8 kDa
- NCBI Accession
- NP_775956
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