OTX2 Protein (His tag)

Catalog No. ABIN2728063

Product Details

Target: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This OTX2 protein is labelled with His tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human OTX2 (full length, N-term HIS tag, transcript variant 1) protein expressed in E. coli.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the N-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Alternative Name: Otx2 (OTX2 Products)

Synonyms: CPHD6 Protein, MCOPS5 Protein, E130306E05Rik Protein, id:ibd2915 Protein, zOtx2 Protein, zgc:136535 Protein, zotx-2 Protein, Xotx-2 Protein, Xotx2 Protein, otx-2 Protein, otx2 Protein, orthodenticle homeobox 2 Protein, orthodenticle homeobox 2 S homeolog Protein, orthodenticle homeobox 2 L homeolog Protein, OTX2 Protein, Otx2 Protein, otx2 Protein, otx2.S Protein, otx2.L Protein

Background: This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine.

Molecular Weight: 31.6 kDa

NCBI Accession: NP_068374

Pathways: Dopaminergic Neurogenesis