RNF34 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2730782

Product Details

Target: RNF34 (Ring Finger Protein 34 (RNF34))

Protein Type: Recombinant

Protein Characteristics: Transcript Variant 2

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This RNF34 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human RFI / RNF34 (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: RNF34 (Ring Finger Protein 34 (RNF34))

Alternative Name: Rfi,rnf34 (RNF34 Products)

Synonyms: CARP-1 Protein, CARP1 Protein, RFI Protein, RIF Protein, RIFF Protein, hRFI Protein, rnf34 Protein, AW061037 Protein, AW536122 Protein, BC004042 Protein, C88279 Protein, Momo Protein, fi35g06 Protein, wu:fi35g06 Protein, zgc:114043 Protein, zgc:171755 Protein, ring finger protein 34 Protein, E3 ubiquitin-protein ligase RNF34 Protein, ring finger protein 34a Protein, ring finger protein 34b Protein, Residual feed intake Protein, RNF34 Protein, rnf34 Protein, Rnf34 Protein, rnf34a Protein, rnf34b Protein, RFI Protein

Background: The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms.

Molecular Weight: 41.5 kDa

NCBI Accession: NP_079402