TCL1A Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)
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- Target See all TCL1A Proteins
- TCL1A (T-Cell Leukemia/lymphoma 1A (TCL1A))
- Protein Type
- Recombinant
- Protein Characteristics
- Transcript Variant 2
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This TCL1A protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human TCL1A / TCL1 (transcript variant 2) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product TCL1A Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- TCL1A (T-Cell Leukemia/lymphoma 1A (TCL1A))
- Alternative Name
- Tcl1a,tcl1 (TCL1A Products)
- Synonyms
- TCL1A Protein, Tcl1a Protein, TCL1 Protein, Tcl1 Protein, T-cell leukemia/lymphoma 1A Protein, T cell lymphoma breakpoint 1 Protein, TCL1A Protein, Tcl1 Protein, Tcl1a Protein
- Background
- Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010].
- Molecular Weight
- 13.3 kDa
- NCBI Accession
- NP_001092195
- Pathways
- Stem Cell Maintenance
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