USP2 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)
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- Target See all USP2 Proteins
- USP2 (Ubiquitin Specific Peptidase 2 (USP2))
- Protein Type
- Recombinant
- Protein Characteristics
- Transcript Variant 2
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This USP2 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human USP2 (transcript variant 2) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product USP2 Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- USP2 (Ubiquitin Specific Peptidase 2 (USP2))
- Alternative Name
- Usp2 (USP2 Products)
- Synonyms
- UBP41 Protein, USP9 Protein, B930035K21Rik Protein, Ubp41 Protein, UBP-t Protein, UBP46 Protein, ubp52 Protein, ubp66 Protein, zgc:92134 Protein, ubiquitin specific peptidase 2 Protein, ubiquitin specific peptidase 2a Protein, USP2 Protein, Usp2 Protein, usp2a Protein
- Background
- This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
- Molecular Weight
- 45.1 kDa
- NCBI Accession
- NP_741994
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