Prokineticin 1 Protein (Prok1)
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- Target See all Prokineticin 1 (Prok1) Proteins
- Prokineticin 1 (Prok1)
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Application
- Functional Studies (Func)
- Sequence
- AVITGACERD VQCGAGTCCA ISLWLRGLRM CTPLGREGEE CHPGSHKVPF FRKRKHHTCP CLPNLLCSRF PDGRYRCSMD LKNINF
- Characteristics
- Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using bovine EJG cells is less than 2.0 μg/mL, corresponding to a specific activity of ＞ 500 IU/mg.
- Purity
- >98 % as determined by SDS-PAGE and HPLC.
- Sterility
- 0.2 μm filtered
- Top Product
- Discover our top product Prok1 Protein
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Prokineticin 1 (Prok1) (AA 20-105) protein (His tag)
Prok1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Prokineticin 1 (Prok1) (AA 20-105) protein (His tag)Prok1 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Prokineticin 1 (Prok1) (AA 1-105) protein (GST tag)Prok1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4, 0.02 % Tween-20
- Storage
- -20 °C
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- Target
- Prokineticin 1 (Prok1)
- Alternative Name
- PROK1 (Prok1 Products)
- Synonyms
- PK1 Protein, zgc:171925 Protein, EGVEGF Protein, PRK1 Protein, EG-VEGF Protein, prokineticin 1 Protein, PROK1 Protein, prok1 Protein, Prok1 Protein
- Background
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Relevance: Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis. {ECO:0000269|PubMed:11259612, ECO:0000269|PubMed:11528470, ECO:0000269|PubMed:15292351, ECO:0000269|PubMed:17289879, ECO:0000269|PubMed:18339712}.
Synonyms: Endocrine-gland-derived vascular endothelial growth factor, Mambakine - Molecular Weight
- 9.7 kDa
- UniProt
- P58294
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