IL29 Protein
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- Target See all IL29 Proteins
- IL29 (Interleukin 29 (IL29))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Application
- Functional Studies (Func)
- Sequence
- GPVPTSKPTT TGKGCHIGRF KSLSPQELAS FKKARDALEE SLKLKNWSCS SPVFPGNWDL RLLQVRERPV ALEAELALTL KVLEAAAGPA LEDVLDQPLH TLHHILSQLQ ACIQPQPTAG PRPRGRLHHW LHRLQEAPKK ESAGCLEASV TFNLFRLLTR DLKYVADGNL CLRTSTHPES T
- Characteristics
- Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by an anti-viral assay using human HepG2 cells infected with encephalomyocarditis is less than 5 ng/mL, corresponding to a specific activity of ＞ 2.0 x 105 IU/mg.
- Purity
- >97 % as determined by SDS-PAGE and HPLC.
- Sterility
- 0.2 μm filtered
- Top Product
- Discover our top product IL29 Protein
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Interleukin 29 (IL29) (AA 22-200) protein (His tag)
IL29 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Interleukin 29 (IL29) (AA 20-200) protein (His tag)Crystallography grade IL29 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Storage
- -20 °C
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- Target
- IL29 (Interleukin 29 (IL29))
- Alternative Name
- IFNL1 (IL29 Products)
- Synonyms
- IL-29 Protein, IL29 Protein, interferon lambda 1 Protein, interferon lambda-1 Protein, interleukin 29 (interferon, lambda 1) Protein, IFNL1 Protein, LOC612539 Protein, IL29 Protein
- Background
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Relevance: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
Synonyms: IFN-lambda-1, Interleukin-29, IL-29 - Molecular Weight
- 19.8 kDa
- UniProt
- Q8IU54
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