LRP4 Protein (AA 1747-1905) (His tag)
LRP4
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
> 90 %
SDS
1 image
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- Target See all LRP4 Proteins
- LRP4 (Low Density Lipoprotein Receptor-Related Protein 4 (LRP4))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1747-1905
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This LRP4 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- YRHKKSKFTD PGMGNLTYSN PSYRTSTQEV KIEAIPKPAM YNQLCYKKEG GPDHNYTKEK IKIVEGICLL SGDDAEWDDL KQLRSSRGGL LRDHVCMKTD TVSIQASSGS LDDTETEQLL QEEQSECSSV HTAATPERRG SLPDTGWKHE RKLSSESQV
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product LRP4 Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- LRP4 (Low Density Lipoprotein Receptor-Related Protein 4 (LRP4))
- Alternative Name
- LRP4 (LRP4 Products)
- Synonyms
- CLSS Protein, LRP-4 Protein, LRP10 Protein, MEGF7 Protein, SOST2 Protein, Megf7 Protein, 6430526J12Rik Protein, D230026E03 Protein, mdig Protein, LRP4 Protein, lrp10 Protein, megf7 Protein, LDL receptor related protein 4 Protein, low density lipoprotein receptor-related protein 4 Protein, LRP4 Protein, Lrp4 Protein, lrp4 Protein
- Background
- Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic mbrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes.
- Molecular Weight
- 22 kDa
- UniProt
- O75096
- Pathways
- Skeletal Muscle Fiber Development
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