eIF4EBP2 Protein (AA 1-120, full length) (GST tag)
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- Target See all eIF4EBP2 (EIF4EBP2) Proteins
- eIF4EBP2 (EIF4EBP2) (Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2))
- Protein Type
- Recombinant
- Protein Characteristics
- full length, AA 1-120
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This eIF4EBP2 protein is labelled with GST tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MSSSAGSGHQ PSQSRAIPTR TVAISDAAQL PHDYCTTPGG TLFSTTPGGT RIIYDRKFLL DRRNSPMAQT PPCHLPNIPG VTSPGTLIED SKVEVNNLNN LNNHDRKHAV GDDAQFEMDI
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product EIF4EBP2 Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- eIF4EBP2 (EIF4EBP2) (Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2))
- Alternative Name
- 4EBP2 (EIF4EBP2 Products)
- Synonyms
- 4ebp2 Protein, MGC75579 Protein, wu:fa55e11 Protein, wu:fp45e09 Protein, MGC78987 Protein, EIF4EBP2 Protein, eIF-4E Protein, Tb06.28P18.1010 Protein, 4EBP2 Protein, PHASII Protein, 2810011I19Rik Protein, 4E-BP2 Protein, AA792569 Protein, BC010348 Protein, PHAS-II Protein, eukaryotic translation initiation factor 4E binding protein 2 Protein, eukaryotic translation initiation factor 4E binding protein 2 L homeolog Protein, eukaryotic initiation factor 4E Protein, eukaryotic translation initiation factor 4E Protein, putative eukaryotic translation initiation factor 4e Protein, eif4ebp2 Protein, Eif4ebp2 Protein, eif4ebp2.L Protein, EIF4EBP2 Protein, eIF-4E Protein, Tb927.6.1870 Protein, LMJF_30_0450 Protein
- Background
- Repressor of translation initiation involved in synaptic plasticity, learning and mory formation . Regulates EIF4E activity by preventing its assbly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation . EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal st cell renewal via its ability to repress translation initiation . Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways .
- Molecular Weight
- 40.3 kDa
- UniProt
- Q13542
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