Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

IL-33 Protein (AA 112-270)

IL33 Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % (SDS-PAGE) SDS Active
Catalog No. ABIN5564348
  • Target See all IL-33 (IL33) Proteins
    IL-33 (IL33) (Interleukin 33 (IL33))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 112-270
    Origin
    • 19
    • 14
    • 3
    • 2
    • 1
    • 1
    • 1
    Human
    Source
    • 25
    • 8
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Application
    SDS-PAGE (SDS)
    Specificity
    Binds to human ST2.
    Cross-Reactivity
    Human
    Characteristics
    Human IL-33 (aa 112-270) is untagged. Amino acids C208 and C232 have been mutated to serine to protect IL-33 from oxidation.
    Purity
    >95 % (SDS-PAGE)
    Endotoxin Level
    <0.01EU/μg purified protein (LAL test, Lonza).
    Top Product
    Discover our top product IL33 Protein
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Comment

    Activates human ST2-dependent NF-kappaB pathway.

    Restrictions
    For Research Use only
  • Format
    Solid
    Concentration
    Lot specific
    Buffer
    Lyophilized. Contains PBS.
    Storage
    4 °C,-20 °C
    Storage Comment
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C.
    Expiry Date
    6 months
  • Target
    IL-33 (IL33) (Interleukin 33 (IL33))
    Alternative Name
    IL-33 (IL33 Products)
    Synonyms
    IL33 Protein, C9orf26 Protein, DVS27 Protein, IL1F11 Protein, NF-HEV Protein, NFEHEV Protein, RP11-575C20.2 Protein, 9230117N10Rik Protein, Il-33 Protein, Il1f11 Protein, RGD1311155 Protein, interleukin 33 Protein, IL33 Protein, Il33 Protein
    Background
    Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL-33 binds to and signals through ST2 (IL-1R1) and its stimulation recruits MYD88, IRAK, IRAK4 and TRAF6, followed by phosphorylation of ERK1 (MAPK3) / ERK2 (MAPK1), p38 (MAPK14) and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases and sepsis. IL-33 facilitates Treg expansion in vitro and in vivo. Recently, IL-33 has been involved in adipocyte differentiation. The biological activity of IL-33 at its receptor ST2 is rapidly terminated in the extracellular environment by its oxidation (formation of two disulfide bridges), resulting in an extensive conformational change that disrupts the ST2 binding site. Mutations at amino acids C208S/C232S protect IL-33 from oxidation and increase its activity.
    Molecular Weight
    ~17kDa
    UniProt
    Q2YEJ5
    Pathways
    Production of Molecular Mediator of Immune Response
You are here:
Support