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IL-37 Protein (partial) (His tag)

IL37 Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE. WB
Catalog No. ABIN5608463
  • Target See all IL-37 (IL37) Proteins
    IL-37 (IL37) (Interleukin 37 (IL37))
    Protein Type
    Recombinant
    Protein Characteristics
    partial
    Origin
    Human
    Source
    • 7
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This IL-37 protein is labelled with His tag.
    Application
    Western Blotting (WB)
    Sequence
    Val 46 - Asp 218
    Purity
    >95 % as determined by SDS-PAGE.
    Endotoxin Level
    Endotoxin level is less than 1.0 EU per ug by the LAL method.
    Top Product
    Discover our top product IL37 Protein
  • Application Notes
    This recombinant protein can be used for WB.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C.
  • Target
    IL-37 (IL37) (Interleukin 37 (IL37))
    Alternative Name
    IL-37 (IL37 Products)
    Synonyms
    FIL1 Protein, FIL1(ZETA) Protein, FIL1Z Protein, IL-1F7 Protein, IL-1H Protein, IL-1H4 Protein, IL-1RP1 Protein, IL-37 Protein, IL1F7 Protein, IL1H4 Protein, IL1RP1 Protein, interleukin 37 Protein, IL37 Protein
    Background
    Interleukin-1 family member 7 (IL1F7b) ,a member of the IL-1 family, is aslo known as interleukin-37, interleukin-1 homolog 4 (IL-1H4), interleukin-1 zeta (IL-1 zeta) and interleukin-1-related protein, which can interact with SMAD3 and bind to IL18R1, but not to IL1R1, with lower affinity than IL18. IL1F7b is a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Therefore,IL1F7b can suppress, or reduce, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spare anti-inflammatory cytokines. Furthermore,IL1F7b can also inhibit dendritic cell activation.
    Molecular Weight
    20.3 kDa
    Gene ID
    27178
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