OTUB1 Protein (AA 2-201, partial) (GST tag)
Quick Overview for OTUB1 Protein (AA 2-201, partial) (GST tag) (ABIN7479615)
Target
See all OTUB1 ProteinsProtein Type
Origin
Source
Application
Purity
-
-
Protein Characteristics
- AA 2-201, partial
-
Purification tag / Conjugate
- This OTUB1 protein is labelled with GST tag.
-
Sequence
- AAEEPQQQKQ EPLGSDSEGV NCLAYDEAIM AQQDRIQQEI AVQNPLVSER LELSVLYKEY AEDDNIYQQK IKDLHKKYSY IRKTRPDGNC FYRAFGFSHL EALLDDSKEL QRFKAVSAKS KEDLVSQGFT EFTIEDFHNT FMDLIEQVEK QTSVADLLAS FNDQSTSDYL VVYLRLLTSG YLQRESKFFE HFIEGGRTVK
-
-
Want other Options for this Protein ?
!Discover Our Predefined Custom Proteins and Custom Protein Services!Your project requires further customization? Contact us and discover our custom protein solutions
-
OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (AA 1-271) protein (GST tag)
OTUB1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (AA 1-271) protein (His-IF2DI Tag)OTUB1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)OTUB1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Buffer
- 6M guanidine hydrochloride, 20mM Tris.
-
Storage
- 4 °C
-
-
- OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))
-
Alternative Name
- Ubiquitin thioesterase OTUB1
-
Background
- Background: Hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains, but not 'Lys-63'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a nuch lower preference compared to 'Lys-48'-linked ubiquitin. R. Synonyms: Deubiquitinating enzyme OTUB1 OTU domain-containing ubiquitin aldehyde-binding protein 1 Otubain-1 Short name=hOTU1 Ubiquitin-specific-processing protease OTUB1.
-
Molecular Weight
- 50.5 kD
-
NCBI Accession
- NM_017670
-
UniProt
- Q96FW1
Target
-
