NUDT1 Protein (AA 1-156) (His tag)
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- Target See all NUDT1 Proteins
- NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-156
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This NUDT1 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Characteristics
- NUDT1, 1-156aa, Human, His tag, E.coli
- Purity
- > 95 % by SDS - PAGE
- Top Product
- Discover our top product NUDT1 Protein
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1mg/ml (determined by BCA)
- Buffer
- Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 2mM DTT, 100mM NaCl
- Storage
- 4 °C
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- Target
- NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))
- Alternative Name
- NUDT1 (NUDT1 Products)
- Synonyms
- mutT Protein, nudT1 Protein, MTH1 Protein, Mth1 Protein, 7,8-dihydro-8-oxoguanine triphosphatase Protein, nudix hydrolase 1 Protein, nudix (nucleoside diphosphate linked moiety X)-type motif 1 Protein, mth1 Protein, Tsp_07498 Protein, nudt1 Protein, 8odp Protein, NUDT1 Protein, Nudt1 Protein
- Background
- NUDT1 is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. It is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. And this protein expressed at much higher levels in proliferating cells than in resting cells. Recombinant human NUDT1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: MTH1, 8-oxo-dGTPase, Nudix motif 1, 7,8-dihydro-8-oxoguanine triphosphatase. NCBI no.: NP_945191
- Molecular Weight
- 20.1kDa (176aa), confirmed by MALDI-TOF
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