MLF1 Protein (AA 1-268) (His tag)
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- Target See all MLF1 Proteins
- MLF1 (Myeloid Leukemia Factor 1 (MLF1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-268
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This MLF1 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Characteristics
- MLF1, 1-268aa, Human, His tag, E.coli
- Purity
- > 85 % by SDS - PAGE
- Top Product
- Discover our top product MLF1 Protein
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5mg/ml (determined by Bradford assay)
- Buffer
- Liquid. 20mM Tris-HCl buffer (pH8.0) containing 40% glycerol, 5mM DTT, 200mM NaCl
- Storage
- 4 °C
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- Target
- MLF1 (Myeloid Leukemia Factor 1 (MLF1))
- Alternative Name
- MLF1 (MLF1 Products)
- Synonyms
- MLF1 Protein, HLS7 Protein, myeloid leukemia factor 1 Protein, myeloid leukemia factor 1 L homeolog Protein, MLF1 Protein, mlf1.L Protein, mlf1 Protein, Mlf1 Protein
- Background
- MLF1 (Myeloid leukemia factor 1) belongs to MLF family, and is a widely expressed negative regulator of cell cycle progression functioning upstream of the tumor suppressor p53. This protein interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. MLF1 normally functions in multi-potent progenitor cells, and its dysregulation may be somewhat responsible for leukemogenesis. Recombinant human MLF1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Myeloid leukemia factor 1,. NCBI no.: NP_071888
- Molecular Weight
- 32.8kDa (288aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
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