MLF1 Protein (AA 1-268) (His tag)

Catalog No. ABIN667346

Product Details

Target: MLF1 (Myeloid Leukemia Factor 1 (MLF1))

Protein Type: Recombinant

Protein Characteristics: AA 1-268

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This MLF1 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Characteristics: MLF1, 1-268aa, Human, His tag, E.coli

Purity: > 85 % by SDS - PAGE

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5mg/ml (determined by Bradford assay)

Buffer: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 40% glycerol, 5mM DTT, 200mM NaCl

Storage: 4 °C

Target Details

Target: MLF1 (Myeloid Leukemia Factor 1 (MLF1))

Alternative Name: MLF1 (MLF1 Products)

Synonyms: MLF1 Protein, HLS7 Protein, myeloid leukemia factor 1 Protein, myeloid leukemia factor 1 L homeolog Protein, MLF1 Protein, mlf1.L Protein, mlf1 Protein, Mlf1 Protein

Background: MLF1 (Myeloid leukemia factor 1) belongs to MLF family, and is a widely expressed negative regulator of cell cycle progression functioning upstream of the tumor suppressor p53. This protein interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. MLF1 normally functions in multi-potent progenitor cells, and its dysregulation may be somewhat responsible for leukemogenesis. Recombinant human MLF1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Myeloid leukemia factor 1,. NCBI no.: NP_071888

Molecular Weight: 32.8kDa (288aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)