MTHFS Protein (AA 1-203) (His tag)
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- Target See all MTHFS Proteins
- MTHFS (5,10-Methenyltetrahydrofolate Synthetase (5-Formyltetrahydrofolate Cyclo-Ligase) (MTHFS))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-203
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This MTHFS protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Characteristics
- MTHFS, 1-203aa, Human, His tag, E.coli
- Purity
- > 95 % by SDS - PAGE
- Top Product
- Discover our top product MTHFS Protein
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/ml (determined by Bradford assay)
- Buffer
- Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 5mM DTT, 30% glycerol, 0.2M NaCl
- Storage
- 4 °C
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- Target
- MTHFS (5,10-Methenyltetrahydrofolate Synthetase (5-Formyltetrahydrofolate Cyclo-Ligase) (MTHFS))
- Alternative Name
- MTHFS (MTHFS Products)
- Synonyms
- MTHFS Protein, 1110034I12Rik Protein, 2310020H23Rik Protein, AI119695 Protein, HsT19268 Protein, 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) Protein, methenyltetrahydrofolate synthetase Protein, 5-formyltetrahydrofolate cyclo-ligase (predicted) Protein, 5-formyltetrahydrofolate cyclo-ligase Protein, 5, 10-methenyltetrahydrofolate synthetase Protein, MTHFS Protein, SPBC1703.08c Protein, ZMO0215 Protein, LBA1507 Protein, Rxyl_1321 Protein, MEMAR_RS07640 Protein, Mjls_4669 Protein, STROP_RS03755 Protein, Mext_0779 Protein, AMF_RS07350 Protein, CKC_02040 Protein, Mthfs Protein
- Background
- MTHFS, also known as 5-formyltetrahydrofolate cyclo-ligase, is a cytosolic protein involved in the formate metabolic process. MTHFS, with a magnesium cofactor, catalyzes the ATP-dependent reaction that reduces 5-formyltetrahydrofolate (5-MTHF) to 5,10-methenyltetrahydrofolate(MTHF). MTHF is the substrate used by MTHFR (methylenetetrahydrofolate reductase) to generate 5-MTHF. MTHF is also a coenzyme used in thymidine biosynthesis by thymidylate synthase (FAD). Recombinant human MTHFS protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: 5-formyltetrahydrofolate cyclo-ligase, Methenyl-THF synthetase. NCBI no.: NP_006432
- Molecular Weight
- 25.4kDa (223aa) confirmed by MALDI-TOF
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