POMC Protein (AA 27-267) (His tag)
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- Target See all POMC Proteins
- POMC (Proopiomelanocortin (POMC))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 27-267
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This POMC protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Characteristics
- POMC, 27-267aa, Human, His tag, E.coli
- Purity
- > 85 % by SDS - PAGE
- Top Product
- Discover our top product POMC Protein
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.25 mg/ml (determined by Bradford assay)
- Buffer
- Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 50% glycerol, 0.2M NaCl
- Storage
- 4 °C
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- Target
- POMC (Proopiomelanocortin (POMC))
- Alternative Name
- POMC (POMC Products)
- Synonyms
- MSH Protein, ACTH Protein, pomc Protein, SI:bZ36D5.1 Protein, SI:bZ36D5.4 Protein, si:bz36d5.2 Protein, BE Protein, Beta-LPH Protein, Clip Protein, Gamma-LPH Protein, Npp Protein, Pomc-1 Protein, Pomc1 Protein, alpha-MSH Protein, alphaMSH Protein, beta-MSH Protein, gamma-MSH Protein, CLIP Protein, LPH Protein, NPP Protein, POC Protein, Pomc2 Protein, proopiomelanocortin a Protein, pro-opiomelanocortin-alpha Protein, proopiomelanocortin Protein, pomca Protein, Pomc Protein, POMC Protein
- Background
- Pro-opiomelanocortin preproprotein, also known as POMC, a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. It regulates the corticosteroid production in the adrenal cortex. Also, POMC is cleaved into ten hormone chains named NPP, gamma-MSH, ACTH, alpha-MSH, CLIP, Lipotropin beta, Lipotropin gamma, beta-MSH, beta endorphin and Met-enkephalin. Defects in the gene that encodes POMC are the cause of POMC deficiency, which is characterized by red hair and adrenal insufficiency. Recombinant human POMC protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Pro-opiomelanocortin preproprotein, ACTH, CLIP, LPH, MSH, NPP, POC. NCBI no.: NP_001030333
- Molecular Weight
- 28.9 kDa (262aa), confirmed by MALDI-TOF (molecular weight on SDS-PAGE will appear higher)
- Pathways
- Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity, Feeding Behaviour
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