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We conclude that brown adipose tissue function in mice does not require the presence of Cox7a1
We demonstrate a developmental isoform switch of COX6A and COX7A subunits in human and mouse skeletal muscle
Data (including data from cells of transgenic mouse embryos) suggest Hif1a (hypoxia inducible factor 1 alpha subunit) up-regulates transcription of heart/muscle isoform Cox7a1 under hypoxia; hypoxic induction of isoform Cox4i2 (show COX4I2 Proteins) is HIF1a (show HIF1A Proteins)-independent.
Deletion of the Cox7a1 isoform results in reduced muscle bioenergetics and hindlimb capillarity
The authors show that homozygous and heterozygous Cox7a1 knockout mice, although viable, have reduced Cox (show CPOX Proteins) activity and develop a dilated cardiomyopathy at 6 weeks of age.
A significasnt decrease in COX7AH polypeptide was observed in the myocardium of infected mice at 110 dpi, the repression being amplified with chronic disease development (330 dpi).
COX7A1 is a novel gene that might play a crucial role in the etiology of lung adenocarcinoma and can serve as a biomarker for lung cancer disease progression
Data found that subunits Cox6a (show COX6A1 Proteins), Cox6b (show COX6B1 Proteins) and Cox7a assembled into pre-existing complex IV, while Cox4-1 (show COX4I1 Proteins) and Cox6c (show COX6C Proteins) subunits assembled into subcomplexes that may represent rate-limiting intermediates.
promoter contains and is regulated by sequence elements typical of contractile muscle as well as the element for the common transcription factor Sp1 (show SP1 Proteins)
While DNA methylation (show HELLS Proteins) of the COX7A1 promoter was increased in muscle from elderly compared with young twins, the opposite was found for COX7A1 mRNA expression
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes.
cytochrome c oxidase subunit 7A1, mitochondrial
, cytochrome c oxidase subunit VIIa-H
, cytochrome c oxidase subunit VIIa-heart
, cytochrome c oxidase subunit VIIa-M
, cytochrome c oxidase subunit VIIa-muscle
, cytochrome c oxidase, subunit VIIa 1
, cytochrome c oxidase subunit VIIa heart/muscle isoform
, cytochrome c oxidase polypeptide VIIa-heart
, cytochrome c oxidase subunit VIIIc