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The gene activation pathway involving GAGA factor is through its direct interaction with dmTAF3.
We identified a novel ANTP (show HOXA7 Proteins)-interacting protein, Bric-a-brac interacting protein 2 (BIP2), that specifically interacts with the YPWM motif of ANTP (show HOXA7 Proteins) in vitro, as well as in vivo, transforming eye to wing tissue.
Data show that like Trf3 (show Tbpl2 Proteins)-depleted zebrafish embryos, Taf3-depleted embryos exhibit multiple developmental defects and fail to undergo hematopoiesis.
Data indicate that TATA box binding protein (show TBP Proteins)-associated factor TAF3 as a direct target of nuclear phosphoinositides (PI).
Study shows that this TAF3 activity is critical for early lineage segregation during stem cell differentiation.
Results report the solution structure of the TAF3-PHD (show PDC Proteins) finger and its complex with an H3K4me3 peptide.
In vitro and cell-based assays identify a domain of TAF3 that mediates coactivator functions targeted by MyoD (show MYOD1 Proteins).
Data show that transcription cofactor TAF3 is required for transcription of the alpha spectrin SPTA1 gene.
Study shows that H3K4me3-TAF3 interactions direct global TFIID (show TBP Proteins) recruitment to active genes, some of which are p53 (show TP53 Proteins) targets. Further analyses show that H3K4me3 enhances p53 (show TP53 Proteins)-dependent transcription by stimulating preinitiation complex formation.
Data identified TAF3 as an evolutionarily conserved negative regulator of p53 (show TP53 Proteins) transcription activation function.
The highly conserved RNA polymerase II transcription factor TFIID (see TAF1\; MIM 313650) comprises the TATA box-binding protein (TBP\; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors (Gangloff et al., 2001
Bric-a-brac interacting protein 2
, TATA binding protein associated factor 3
, TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor
, transcription initiation factor TFIID subunit 3
, 140 kDa TATA box-binding protein-associated factor
, RNA polymerase II transcription factor, TFIID subunit
, TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
, TBP-associated factor 3
, transcription initiation factor TFIID 140 kDa subunit
, RNA polymerase II transcription factor TAFII140