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HIST2H2BE antibody (N-Term)
HIST2H2BE
Reactivity: Human
WB
Host: Rabbit
Polyclonal
RB41930
unconjugated
Product Details anti-HIST2H2BE Antibody
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Target
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HIST2H2BE
(Histone H2B Type 2-E (HIST2H2BE))
Binding Specificity
All epitopes for HIST2H2BE antibodies
AA 12-40, N-Term
Reactivity
All reactivities for HIST2H2BE antibodies
Human
Host
All hosts for HIST2H2BE antibodies
Rabbit
Clonality
All clonalities for HIST2H2BE antibodies
Polyclonal
Conjugate
All conjugates for HIST2H2BE antibodies
This HIST2H2BE antibody is un-conjugated
Application
All applications for HIST2H2BE antibodies
Western Blotting (WB)
Predicted Reactivity
M
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This HIST2H2BE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human HIST2H2BE.
Clone
RB41930
Isotype
Ig Fraction
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Alternatives
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Application Details
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Application Notes
WB: 1:1000
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
References for anti-HIST2H2BE antibody (ABIN1881418)
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Kim, Guermah, McGinty, Lee, Tang, Milne, Shilatifard, Muir, Roeder : "RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. " in: Cell , Vol. 137 , Issue 3 , pp. 459-71 , (2009 ) (PubMed ).
Pankratova, Manuĭlova, Stepchenko : "[Role of transcription factors binding sites in no-mediated histone H2B promoter repression]. " in: Molekuliarnaia biologiia , Vol. 43 , Issue 2 , pp. 368-73 , (2009 ) (PubMed ).
Dai, Yu, Goh, Chng, Tan, Fu, Zheng, Luo : "Histone 2B (H2B) expression is confined to a proper NAD+/NADH redox status. " in: The Journal of biological chemistry , Vol. 283 , Issue 40 , pp. 26894-901 , (2008 ) (PubMed ).
Zhao, Lang, Ito, Bonnet, Metzger, Sawatsubashi, Suzuki, Le Guezennec, Stunnenberg, Krasnov, Georgieva, Schüle, Takeyama, Kato, Tora, Devys : "A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. " in: Molecular cell , Vol. 29 , Issue 1 , pp. 92-101 , (2008 ) (PubMed ).
Kawasaki, Schiltz, Chiu, Itakura, Taira, Nakatani, Yokoyama : "ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation. " in: Nature , Vol. 405 , Issue 6783 , pp. 195-200 , (2000 ) (PubMed ).
Target Details for HIST2H2BE
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Target
HIST2H2BE
(Histone H2B Type 2-E (HIST2H2BE))
Alternative Name
HIST2H2BE (HIST2H2BE Products )
Synonyms
RGD1562346 antibody, AV127319 antibody, H2b-613 antibody, T25626 antibody, DKFZp469C0528 antibody, H2b antibody, GL105 antibody, H2B antibody, H2B.1 antibody, H2BFQ antibody, H2BGL105 antibody, H2BQ antibody, histone cluster 2 H2B family member E antibody, histone cluster 2, H2be antibody, histone cluster 1, H2bl antibody, histone cluster 2 H2B family member e antibody, histone H2B antibody, Hist2h2be antibody, HIST2H2BE antibody, Hist1h2bl antibody, H2B antibody
Background
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.
Molecular Weight
13920
NCBI Accession
NP_003519
UniProt
Q16778
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