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HCV Core Protein antibody (N-Term)

HCV C Reactivity: Hepatitis C Virus (HCV) EIA Host: Mouse Monoclonal 6A1 unconjugated
Catalog No. ABIN111711
  • Target See all HCV Core Protein (HCV C) Antibodies
    HCV Core Protein (HCV C) (Hepatitis C Virus Core Protein (HCV C))
    Binding Specificity
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    AA 1-80, N-Term
    Reactivity
    • 51
    • 4
    • 3
    • 1
    Hepatitis C Virus (HCV)
    Host
    • 38
    • 17
    • 3
    Mouse
    Clonality
    • 38
    • 20
    Monoclonal
    Conjugate
    • 32
    • 9
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HCV Core Protein antibody is un-conjugated
    Application
    • 40
    • 28
    • 12
    • 12
    • 9
    • 7
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Enzyme Immunoassay (EIA)
    Purification
    Protein A chromatography
    Immunogen
    Recombinant protein
    Clone
    6A1
    Isotype
    IgG2a
    Top Product
    Discover our top product HCV C Primary Antibody
  • Application Notes
    Suitable for use in ELISA employing native viral lysates. Does not work in Western blot.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    1X PBS, pH 7.2 with 0.01 % sodium azide as preservative
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Nattermann, Nischalke, Hofmeister, Ahlenstiel, Zimmermann, Leifeld, Weiss, Sauerbruch, Spengler: "The HLA-A2 restricted T cell epitope HCV core 35-44 stabilizes HLA-E expression and inhibits cytolysis mediated by natural killer cells." in: The American journal of pathology, Vol. 166, Issue 2, pp. 443-53, (2005) (PubMed).

  • Target
    HCV Core Protein (HCV C) (Hepatitis C Virus Core Protein (HCV C))
    Alternative Name
    HCV Core Protein (HCV C Products)
    Target Type
    Viral Protein
    Background
    The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein, it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.Synonyms: Hepatitis C Virus core protein
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