SERPINB9 antibody

Catalog No. ABIN2192172

Product Details anti-SERPINB9 Antibody

Target: SERPINB9 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SERPINB9 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Sterility: 0.2 μm filtered

Application Details

Application Notes: For flow cytometry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Restrictions: For Research Use only

Handling

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Expiry Date: 12 months

References for anti-SERPINB9 antibody (ABIN2192172)

Zhang, Byrne, Liu, Wang, Oxenius, Ashton-Rickardt: "Differential survival of cytotoxic T cells and memory cell precursors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 6, pp. 3483-91, (2007) (PubMed).

Zhang, Liu, Park, Wang, Byrne, Murmann, Bahr, Peter, Olson, Belaaouaj, Ashton-Rickardt: "Serine protease inhibitor 6-deficient mice have increased neutrophil immunity to Pseudomonas aeruginosa." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 7, pp. 4390-6, (2007) (PubMed).

Target Details for SERPINB9

Target: SERPINB9 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9))

Alternative Name: Spi-6 (SERPINB9 Products)

Synonyms: SERPINB9 antibody, BB283241 antibody, CAP-3 antibody, CAP3 antibody, PI-9 antibody, PI9 antibody, Spi6 antibody, ovalbumin antibody, serpin family B member 9 antibody, serpin peptidase inhibitor, clade B (ovalbumin), member 9 antibody, serine (or cysteine) peptidase inhibitor, clade B, member 9 antibody, Serpinb9 antibody, SERPINB9 antibody

Background: The polyclonal antibody recognizes mouse Spi-6, also known as serpin B9, a cytoplasmic serine protease inhibitor of ~42 kD. Spi-6 is expressed in dendritic cells, lymphocytes and specific cell types at immune- privileged sites. It inactivates granzyme B, a natural occurring inducer of programmed cell death. As such, Spi-6 functions as anti-apoptotic protein. In cytotxic T cells (CTL), Spi-6 is required to protect clonal bursts (expansion) from granzyme B induced cell death. However, it is not required for the development of memory cells. Expression of SPI-6 is of crucial importance in the escape of several tumors from a CTL response and is, therefore, a parameter that influences the feasibility of CTL-mediated immunotherapy of cancer. The polyclonal antibody shows no crossreactivity with mouse proteins related to Spi-6. Aliases Cytoplasmic antiproteinase 3, serpin B9, PI-9 Immunogen Recombinant GST-Spi-6