SLC11A2
Reactivity: Human
ELISA
Host: Rabbit
Polyclonal
HRP
Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Buffer
In 1x PBS, pH 7.4
Handling Advice
Aliquot to avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Montalbetti, Simonin, Simonin, Awale, Reymond, Hediger: "Discovery and characterization of a novel non-competitive inhibitor of the divalent metal transporter DMT1/SLC11A2." in: Biochemical pharmacology, Vol. 96, Issue 3, pp. 216-24, (2015) (PubMed).
Montalbetti, Simonin, Dalghi, Kovacs, Hediger: "Development and Validation of a Fast and Homogeneous Cell-Based Fluorescence Screening Assay for Divalent Metal Transporter 1 (DMT1/SLC11A2) Using the FLIPR Tetra." in: Journal of biomolecular screening, Vol. 19, Issue 6, pp. 900-908, (2014) (PubMed).
Howitt, Putz, Lackovic, Doan, Dorstyn, Cheng, Yang, Chan-Ling, Silke, Kumar, Tan: "Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 36, pp. 15489-94, (2009) (PubMed).
Foot, Dalton, Shearwin-Whyatt, Dorstyn, Tan, Yang, Kumar: "Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2." in: Blood, Vol. 112, Issue 10, pp. 4268-75, (2008) (PubMed).
Target
SLC11A2
(Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 (SLC11A2))