This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This LRCH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304-333 amino acids from the Central region of human LRCH1.
LRCH1
Reactivity: Human
WB, ELISA
Host: Rabbit
Polyclonal
Biotin
Application Notes
WB: 1:1000
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Zintzaras, Kitsios, Ziogas, Rodopoulou, Karachalios: "Field synopsis and synthesis of genetic association studies in osteoarthritis: the CUMAGAS-OSTEO information system." in: American journal of epidemiology, Vol. 171, Issue 8, pp. 851-8, (2010) (PubMed).
Jiang, Shi, Nakajima, Dai, Wei, Malizos, Qin, Miyamoto, Kamatani, Liu, Tsezou, Nakamura, Ikegawa: "Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility." in: Journal of human genetics, Vol. 53, Issue 1, pp. 42-7, (2007) (PubMed).
Ikegawa: "New gene associations in osteoarthritis: what do they provide, and where are we going?" in: Current opinion in rheumatology, Vol. 19, Issue 5, pp. 429-34, (2007) (PubMed).
Snelling, Sinsheimer, Carr, Loughlin: "Genetic association analysis of LRCH1 as an osteoarthritis susceptibility locus." in: Rheumatology (Oxford, England), Vol. 46, Issue 2, pp. 250-2, (2007) (PubMed).
Spector, Reneland, Mah, Valdes, Hart, Kammerer, Langdown, Hoyal, Atienza, Doherty, Rahman, Nelson, Braun: "Association between a variation in LRCH1 and knee osteoarthritis: a genome-wide single-nucleotide polymorphism association study using DNA pooling." in: Arthritis and rheumatism, Vol. 54, Issue 2, pp. 524-32, (2006) (PubMed).
This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms.