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- Target See all Renin (REN) Kits
- Renin (REN)
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Reactivity
- Mouse
- Detection Method
- Fluorometric
- Application
- Fluorescence Resonance Energy Transfer Microscopy (FRET)
- Brand
- SensoLyte®
- Characteristics
- The SensoLyte® 520 Mouse Renin Assay Kit provides a convenient assay for high throughput screening of renin inhibitors and for continuous assay of mouse renin activity using a 5-FAM/QXL™520 FRET peptide. In the FRET peptide the fluorescence of 5-FAM is quenched by QXL™520. Upon cleavage into two separate fragments by renin, the fluorescence of 5-FAM is recovered, and can be monitored at excitation/emission = 490/520 nm.
- Top Product
- Discover our top product REN ELISA Kit
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- Comment
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FRET-based Assay Kit
- Restrictions
- For Research Use only
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- Storage
- -80 °C
- Storage Comment
- Store all kit components at -20 °C, except for Component C. Store Component C at -80 °C. Protect Components A, B, F, and G from light and moisture. Component D can be stored at room temperature for convenience.
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Angiotensin II receptor blocker improves the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice." in: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 114, Issue 7, pp. 844-57, (2013) (PubMed).
: "Primary aldosteronism and impaired natriuresis in mice underexpressing TGF?1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 14, pp. 5600-5, (2013) (PubMed).
: "VDR attenuates acute lung injury by blocking Ang-2-Tie-2 pathway and renin-angiotensin system." in: Molecular endocrinology (Baltimore, Md.), Vol. 27, Issue 12, pp. 2116-25, (2013) (PubMed).
: "Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension." in: Nature medicine, Vol. 18, Issue 2, pp. 286-90, (2012) (PubMed).
: "Vitamin D receptor signaling in podocytes protects against diabetic nephropathy." in: Journal of the American Society of Nephrology : JASN, Vol. 23, Issue 12, pp. 1977-86, (2012) (PubMed).
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Angiotensin II receptor blocker improves the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice." in: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 114, Issue 7, pp. 844-57, (2013) (PubMed).
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- Target
- Renin (REN)
- Alternative Name
- Renin (REN Products)
- Synonyms
- HNFJ2 Kit, RATRENAA Kit, RENAA Kit, Ren1 Kit, D19352 Kit, Ren Kit, Ren-1 Kit, Ren-A Kit, Ren1c Kit, Ren1d Kit, Rn-1 Kit, Rnr Kit, renin Kit, renin 1 structural Kit, REN Kit, Ren Kit, Ren1 Kit, ren Kit
- Background
- Renin, a highly specific aspartyl protease, cleaves angiotensinogen, to yield angiotensin I. Angiotensin I is further converted into angiotensin II by ACE (Angiotensin Converting Enzyme). Angiotensin II constricts blood vessels leading to increased blood pressure. Discovery of new renin inhibitors for treatment of hypertension is a promising area of research.
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