HSP90AA1 antibody (AA 229-263)

Catalog No. ABIN1945096

Product Details anti-HSP90AA1 Antibody

Target: HSP90AA1 (Heat Shock Protein 90kDa alpha (Cytosolic), Class A Member 1 (HSP90AA1))

Binding Specificity: AA 229-263

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSP90AA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This hsp90a.1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 229-263 amino acids from the Central region of human (DANRE) hsp90a.1.

Clone: RB47443

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. WB: 1:2000. WB: 1:1000. WB: 1:2000. IHC-P: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-HSP90AA1 antibody (ABIN1945096)

Howe, Clark, Torroja, Torrance, Berthelot, Muffato, Collins, Humphray, McLaren, Matthews, McLaren, Sealy, Caccamo, Churcher, Scott, Barrett, Koch, Rauch, White, Chow, Kilian, Quintais, Guerra-Assunção, Zhou, Gu, Yen, Vogel, Eyre, Redmond, Banerjee, Chi, F: "The zebrafish reference genome sequence and its relationship to the human genome." in: Nature, Vol. 496, Issue 7446, pp. 498-503, (2013) (PubMed).

Etard, Roostalu, Strähle: "Shuttling of the chaperones Unc45b and Hsp90a between the A band and the Z line of the myofibril." in: The Journal of cell biology, Vol. 180, Issue 6, pp. 1163-75, (2008) (PubMed).

Etard, Behra, Fischer, Hutcheson, Geisler, Strähle: "The UCS factor Steif/Unc-45b interacts with the heat shock protein Hsp90a during myofibrillogenesis." in: Developmental biology, Vol. 308, Issue 1, pp. 133-43, (2007) (PubMed).

Lele, Hartson, Martin, Whitesell, Matts, Krone: "Disruption of zebrafish somite development by pharmacologic inhibition of Hsp90." in: Developmental biology, Vol. 210, Issue 1, pp. 56-70, (1999) (PubMed).

Krone, Sass: "HSP 90 alpha and HSP 90 beta genes are present in the zebrafish and are differentially regulated in developing embryos." in: Biochemical and biophysical research communications, Vol. 204, Issue 2, pp. 746-52, (1994) (PubMed).

Target Details for HSP90AA1

Target: HSP90AA1 (Heat Shock Protein 90kDa alpha (Cytosolic), Class A Member 1 (HSP90AA1))

Alternative Name: hsp90a.1 (HSP90AA1 Products)

Synonyms: EL52 antibody, HSP86 antibody, HSP89A antibody, HSP90A antibody, HSP90N antibody, HSPC1 antibody, HSPCA antibody, HSPCAL1 antibody, HSPCAL4 antibody, HSPN antibody, Hsp89 antibody, Hsp90 antibody, LAP2 antibody, Hsp86 antibody, Hspca antibody, htpG antibody, 86kDa antibody, 89kDa antibody, AL024080 antibody, AL024147 antibody, Hsp86-1 antibody, hsp4 antibody, HSP90 antibody, HSP90AA1 antibody, fb17b01 antibody, hsp90 antibody, hsp90a antibody, hsp90a.1 antibody, hsp90alpha antibody, wu:fb17b01 antibody, zgc:86652 antibody, Hsp90alpha antibody, heat shock protein 90 alpha family class A member 1 antibody, heat shock protein 90, alpha (cytosolic), class A member 1 antibody, Heat Shock Protein 90, cytosolic antibody, heat shock protein 90A antibody, molecular chaperone antibody, heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1 antibody, heat shock protein HSP 90-alpha antibody, heat shock protein 90kDa alpha (cytosolic), class A member 1 antibody, HSP90AA1 antibody, Hsp90aa1 antibody, HSP90A antibody, hsp90A antibody, hsp90aa1.1 antibody, LOC108698781 antibody

Background: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity). Plays a key role in slow and fast muscle development in the embryo. Plays a role in myosin expression and assembly.

Molecular Weight: 83319

Gene ID: 30591

UniProt: Q90474

Pathways: M Phase, Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals