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There is a significant association in the expression of P-Rex1 and MMP10 (show MMP10 ELISA Kits) in human luminal breast cancer, and their co-expression is indicative of poor prognosis.
Data suggest that PREX1 and PREX2 (show DEPDC2 ELISA Kits) share similarities in amino acid sequence, domain structure, activation by PIP(3) [phosphatidylinositol 3,4,5-triphosphate] and G-protein-coupled receptors beta/gamma subunits; expression of PREX1 and PREX2 (show DEPDC2 ELISA Kits) is altered in many cancers. [REVIEW]
upon ligation of the T-cell antigen receptor (TCR), the TCR associates with and transactivates CXCR4 (show CXCR4 ELISA Kits) via phosphorylation of S339-CXCR4 (show CXCR4 ELISA Kits) in order to activate a PREX1-Rac1-signaling pathway that stabilizes interleukin-2(IL-2 (show IL2 ELISA Kits)), IL-4 (show IL4 ELISA Kits), and IL-10 (show IL10 ELISA Kits) messenger RNA (mRNA) transcripts.
data point to multiple mechanisms of PREX1 negative regulation by PAKs within receptor tyrosine kinase and GPCR-stimulated signaling pathways
PREX1 overexpression reduced staurosporine-induced apoptosis whereas its shRNA knockdown promoted apoptosis in response to staurosporine or the anti-estrogen drug tamoxifen.
An unexpected role for P-Rex1 and Rac1 activation in the genesis of prostate cancer stem cells and resistance to bevacizumab and sunitinib.
P-Rex1 contributes to the spatiotemporal localization of type I PKA, which tightly regulates this guanine exchange factor by a multistep mechanism.
findings suggest a vital role of P-Rex1 signaling in CA1 (show CA1 ELISA Kits) LTD that is critical for social behavior and cognitive function and offer new insight into the etiology of ASDs
The P-Rex1-Rac1 interface is critical for Rac1 activation in breast cancer cells.
P-REX1 promotes both PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) and MEK (show MAP2K1 ELISA Kits)/ERK (show EPHB2 ELISA Kits) signaling in breast cancer.
A novel mechanism of P-Rex1 regulation through the GPCR (show GPBAR1 ELISA Kits)-adaptor protein Norbin (show NCDN ELISA Kits).
Tiam1 and P-Rex1 promote Rac1 anti- and pro-migratory signalling cascades.
regulates GPCR-driven Rac signalling and actin polarity in neutrophils
Platelet P-Rex and Vav (show VAV1 ELISA Kits) family Rac (show AKT1 ELISA Kits)-GEFs play important proinflammatory roles in leukocyte recruitment.
We have elucidated a proliferative role of P-Rex1 when Rac1 is deleted in melanoblasts.
P-Rex1 may serve as a biomarker to predict response to single-agent PI3K inhibitors within a subset of breast cancers.
In vivo, in an ischemia-reperfusion-induced model of acute kidney injury, abolished selectin-mediated integrin activation contributed to decreased neutrophil recruitment and reduced kidney damage in P-Rex1-deficient mice.
P-rex1 expressed in endothelial cells is a critical mediator of vascular barrier disruption by an upstream pathway.
Data conclude that P-Rex1 has an important role in melanoblast migration and cancer progression to metastasis in mice and humans.
The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
, phosphatidylinositol 3,4,5-trisphosphate-dependent RAC exchanger 1
, phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein-like
, phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
, ptdIns(3,4,5)-dependent Rac exchanger 1
, SET domain containing 6