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Browse our anti-Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) Antibodies

Full name:
anti-Spectrin, Beta, Non-erythrocytic 2 Antibodies (SPTBN2)
On www.antibodies-online.com are 154 Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) Antibodies from 7 different suppliers available. Additionally we are shipping and many more products for this protein. A total of 155 Spectrin, Beta, Non-erythrocytic 2 products are currently listed.
Synonyms:
GTRAP41, mKIAA0302, SCA5, Spnb3
list all antibodies Gene Name GeneID UniProt
SPTBN2 20743  
SPTBN2 6712 O15020
SPTBN2 29211 Q9QWN8

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More Antibodies against Spectrin, Beta, Non-erythrocytic 2 Interaction Partners

Mouse (Murine) Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) interaction partners

  1. TGF-beta (show TGFB1 Antibodies)/beta2-spectrin/CTCF (show CTCF Antibodies)-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome.

  2. Study shows a direct interaction between beta-III spectrin and erythroid ankyrin (show ANK1 Antibodies) in the cerebellum and to demonstrate a critical role for beta-III spectrin in maintaining ankyrin R (show ANK1 Antibodies) throughout the Purkinje cell dendritic tree.

  3. This study demonistrated that beta-III spectrin is critical for development of purkinje cell dendritic tree and spine morphogenesis.

  4. Beta-III spectrin mutation L253P interferes with binding to Arp1 (show APOBEC2 Antibodies) and protein trafficking from the Golgi.

  5. betaIII spectrin disruption impairs synaptogenesis by disturbing the intracellular pathways selectively regulating protein trafficking to the synapse

Human Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) interaction partners

  1. This study indicates that high-affinity actin binding of L253P beta-III-spectrin is a likely driver of neurodegeneration.

  2. beta2-Spectrin, a TGF-beta (show TGFB1 Antibodies) mediator and signaling molecule, is cleaved and activated by caspase-3 (show CASP3 Antibodies)/7, consequently enhancing apoptosis and transcriptional control to determine cell fate upon liver damage.

  3. TGF-beta (show TGFB1 Antibodies)/beta2-spectrin/CTCF (show CTCF Antibodies)-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome.

  4. investigated using either targeted next generation sequencing or trio (show TRIO Antibodies)-based exome sequencing and were found to have mutations in three different genes, KCNC3 (show KCNC3 Antibodies), ITPR1 (show ITPR1 Antibodies) and SPTBN2

  5. First Japanese spinocerebellar ataxia (show USP14 Antibodies) type 5 (SCA5) family with a novel heterozygous three-nucleotide in-frame deletion mutation in the SPTBN2 gene.

  6. A homozygous SPTBN2 nonsense mutation underlying infantile ataxia (show USP14 Antibodies) and psychomotor delay in a human family.

  7. Mutant beta-III spectrin causes mislocalization and dysfunction of mGluR1alpha at dendritic spines.

  8. A novel missense mutation within a SPTBN2 spectrin repeat encoded by exon 12 was found in a family with spinocerebellar ataxia (show USP14 Antibodies) type 5.

  9. the identification of SPARCA1 and normal heterozygous carriers of the stop codon in SPTBN2 provides insights into the mechanism of molecular dominance in SCA5 and demonstrates that the cell-specific repertoire of spectrin subunits

  10. betaIII spectrin regulates the structural integrity and the secretory protein transport of the Golgi complex

Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) Antigen Profile

Antigen Summary

Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.

Alternative names and synonyms associated with Spectrin, Beta, Non-erythrocytic 2 (SPTBN2)

  • spectrin beta, non-erythrocytic 2 (Sptbn2) antibody
  • spectrin, beta, non-erythrocytic 2 (SPTBN2) antibody
  • spectrin, beta, non-erythrocytic 2 (Sptbn2) antibody
  • GTRAP41 antibody
  • mKIAA0302 antibody
  • SCA5 antibody
  • Spnb3 antibody

Protein level used designations for SPTBN2

beta-spectrin 3 , spectrin beta 3 , spectrin beta chain, brain 2 , beta-III spectrin , glutamate transporter EAAT4-associated protein 41 , spectrin beta chain, non-erythrocytic 2 , spectrin, non-erythroid beta chain 2 , spinocerebellar ataxia 5 protein , SPNB-3 , beta SpIII sigma 1 , spectrin-like protein GTRAP41

GENE ID SPECIES
20743 Mus musculus
6712 Homo sapiens
29211 Rattus norvegicus
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