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WASH deficiency impairs the association of RNF2 (show RNF2 Proteins) with AMBRA1 (show AMBRA1 Proteins) to impede AMBRA1 (show AMBRA1 Proteins) degradation.
WASH complex regulates Arp2 (show AICDA Proteins)/3 complex and is required for cytokinesis and polar body extrusion.
WASH is required for the differentiation commitment of hematopoietic stem cells by acting as an upstream regulator to modulate c-Myc (show MYC Proteins) transcription.
WASH can suppress Beclin 1 (show BECN1 Proteins) ubiquitination to inactivate Vps34 (show PIK3C3 Proteins) activity leading to suppression of autophagy.
WASH is a newly recognized regulator of T cell receptor, CD28 (show CD28 Proteins), LFA-1 (show ITGAL Proteins), and GLUT1 (show SLC2A1 Proteins) endosome-to-membrane recycling.
WASH-mediated F-actin is requisite for the integrity of both endosomal and lysosomal networks in mammalian cells.
WASH is a bimodular protein and a component of the BLOC-1 complex in which the C terminus is involved in Arp2/3-mediated actin nucleation, whereas the N-terminal portion is required for its regulation and localization in the cells
show that WASH generates an actin network on a restricted domain of sorting and recycling endosomes.
Stress-internalized EGFR co-segregates with exogenously expressed pre-melanosomal markers OA1 and fibrillar PMEL, following early endosomal sorting by the actin polymerization-promoting WASH complex
FAM21 not only functions as an integral component of the cytoplasmic WASH complex, but also modulates NF-kappaB (show NFKB1 Proteins) gene transcription in the nucleus.
The WASH-VPEF/FAM21-retromer complexe mediates endosome fission and sorting of virus-containing vesicles prior to virus core uncoating in the cytoplasm.
The USP7 deubiquitinating enzyme is an integral component of the MAGE-L2-TRIM27 ligase and is essential for WASH-mediated endosomal actin assembly and protein recycling.
WASH and the exocyst complex are required for matrix degradation by an exocytic mechanism that involves tubular connections between MT1-MMP (show MMP14 Proteins)-positive late endosomes and the plasma membrane in contact with the matrix.
Data show that a component of the WASH regulatory complex (SHRC), FAM21, directly interacts with the retromer CSC protein VPS35 (show vps35 Proteins).
WASH and Arp2 (show ACTR2 Proteins)/3 regulates integrin alpha5beta1-mediated invasive cell migration.
Actin polymerization by WASH influences the shape and maturation of endosomes, and highlights a previously unrecognized role for WASH and the Arp2 (show ACTR2 Proteins)/3 complex in the degradative steps of endocytic trafficking.
WASH exists in a multiprotein complex containing FAM21, which links WASH to endosomes and is required for WASH-dependent retromer-mediated sorting.
Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (By similarity).
WAS protein family homolog 1
, WAS protein family homolog 2
, CXYorf1-like protein on chromosome 9
, FLJ00075 protein
, family with sequence similarity 39, member E
, WAS protein family homolog 2 pseudogene
, family with sequence similarity 39, member B