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Human EGR1 ELISA Kit for Sandwich ELISA - ABIN414979
Zhang, Zhu, Ba, Chen, Zhou, Cao, Wang, Ren, Wu: Gekko-sulfated glycopeptide inhibits tumor angiogenesis by targeting basic fibroblast growth factor. in The Journal of biological chemistry 2012
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Mouse (Murine) EGR1 ELISA Kit for Sandwich ELISA - ABIN415740
Moya-Pérez, Romo-Vaquero, Tomás-Barberán, Sanz, García-Conesa: Hepatic molecular responses to Bifidobacterium pseudocatenulatum CECT 7765 in a mouse model of diet-induced obesity. in Nutrition, metabolism, and cardiovascular diseases : NMCD 2013
Human EGR1 ELISA Kit for Sandwich ELISA - ABIN856951
Okuyama, Matsuda, Yamashita, Moriguchi-Goto, Sameshima, Iwakiri, Matsuura, Sato, Asada: Human Coronary Thrombus Formation Is Associated With Degree of Plaque Disruption and Expression of Tissue Factor and Hexokinase II. in Circulation journal : official journal of the Japanese Circulation Society 2015
Egr-1 silencing through intracoronary delivery of a targeting DNAzyme at the time of reperfusion following acute myocardial ischemia decreases myocardial inflammation and apoptosis leading to improved cardiac function.
Intracoronary delivery of DNAzymes targeting human EGR-1 reduces infarct size following myocardial ischaemia reperfusion.
Data suggest that Egr-1 protein levels may be tightly regulated in an attempt to diminish neurotoxicity or to enhance plasticity in newborn animals.
The Egr-1 is essential for CSE-induced MUC5AC production in HBE (show HBe1 ELISA Kits) cells likely through interaction with and modulation of AP-1 (show FOSB ELISA Kits), and re-emphasize targeting Egr-1 as a novel therapeutic strategy for COPD (show ARCN1 ELISA Kits).
Finally, the authors show that EGFR (show EGFR ELISA Kits)-ERK1/2 (show MAPK1/3 ELISA Kits) and beta1-integrin signaling are the main pathways used for bacteria-mediated EGR1 upregulation.
Early growth response (Egr)-1 is essential for fibrotic responses to Transforming growth factor (TGF)-beta (show TGFB1 ELISA Kits). Egr-1 mediates TGF-beta1 (show TGFB1 ELISA Kits)-induced COL1A1 (show COL1A1 ELISA Kits) and COL1A2 (show COL1A2 ELISA Kits) mRNA expression and acid-soluble collagen production in buccal mucosal fibroblasts (BMFs).The epigallocatechin-3-gallate (EGCG) can block TGF-beta1 (show TGFB1 ELISA Kits)-induced collagen production by attenuating Egr-1 expression in BMFs.
Along with the reduction of ovarian cancer-2/disabled homolog 2 (DOC-2 (show DAB2 ELISA Kits)/DAB2) interactive protein (DAB2IP (show DAB2IP ELISA Kits)) expression, EGR-1 gene was upregulated in FI-treated cells. On the other hand, downregulation of EGR-1 gene expression sensitized radioresistant cells to IR accompanied by DAB2IP (show DAB2IP ELISA Kits) overexpression and STAT3 (show STAT3 ELISA Kits) inactivation. In addition, NF-kappaB (show NFKB1 ELISA Kits) inhibitor, BAY11-7082 enhanced resistant cells' radiosensitivity and chemos...
ROS (show ROS1 ELISA Kits) activation of the MAPK (ERK (show MAPK1 ELISA Kits)-1 (show MAPK3 ELISA Kits)/2)/Egr-1 pathway is a main player in the regulatory mechanism for cigarette smoke extract-induced PlGF (show PGF ELISA Kits) production. Antioxidants could partly abolish these effects.
adipose tissue-derived mesenchymal stem cells (AT-MSCs) from diabetic patients may contribute to microvascular damage and delay wound healing through the overexpression of EGR-1.
KLF12 (show KLF12 ELISA Kits) promotes tumor growth by directly activating early growth response protein 1 (EGR1). The levels of KLF12 (show KLF12 ELISA Kits) and EGR1 correlate synergistically with a poor prognosis. These results indicate that KLF12 (show KLF12 ELISA Kits) likely plays an important role in CRC (show CALR ELISA Kits) and could serve as a potential prognostic marker and therapeutic target.
Shikonin induces apoptosis in some lung cancer cells via activation of FOXO3a (show FOXO3 ELISA Kits)/EGR1/SIRT1 (show SIRT1 ELISA Kits) signaling, and AKT (show AKT1 ELISA Kits) and p300 (show EP300 ELISA Kits) negatively regulate this process via Bim (show BCL2L11 ELISA Kits) upregulation.
Inhibition of mTORC1-mediated 4EBP1 (show EIF4EBP1 ELISA Kits) phosphorylation leads to decreased expression of c-MYC (show MYC ELISA Kits) and subsequent upregulation of the proapoptotic BCL2 (show BCL2 ELISA Kits) family member PUMA (show BBC3 ELISA Kits), whereas inhibition of mTORC2 (show CRTC2 ELISA Kits) results in nuclear factor-kappaB-mediated expression of the Early Growth Response 1 (EGR1) gene, which encodes a transcription factor that binds and transactivates the proapoptotic BCL2L11 (show BCL2L11 ELISA Kits) locus encoding BIM (show BCL2L11 ELISA Kits).
Conversely, siRNA-mediated Klotho (show KL ELISA Kits) silencing up-regulated Egr-1, FN, and Col (show HDAC1 ELISA Kits) I expression and the p-Smad3/Smad3 (show SMAD3 ELISA Kits) ratio. Moreover, the effects of si-Klotho (show KL ELISA Kits) on Egr-1 expression were abolished by the TGF-beta1 (show TGFB1 ELISA Kits) inhibitor SB-431542. Klotho (show KL ELISA Kits) overexpression can prevent mesangial ECM (show MMRN1 ELISA Kits) production in high-glucose-treated human MCs (show SMCP ELISA Kits), an effect that has been partially attributed to Egr-1 down-regulation facilitated by TGF-beta1 (show TGFB1 ELISA Kits)/Smad3 (show SMAD3 ELISA Kits) s...
EGR1 can promote skeletal muscle satellite cell differentiation through positive regulation of MyoG (show MYOG ELISA Kits) gene expression.
Chronic hypoxia induces Egr-1 via activation of ERK1/2 (show MAPK1/3 ELISA Kits) and contributes to pulmonary vascular remodeling.
The authors conclude that Egr-1 protein expression is very sensitive to upregulation by hypoxia in pulmonary artery adventitial fibroblasts and that it plays an important role in the autonomous growth phenotype induced by hypoxia in these cells.
EGR-1's expression prior to ovulation and its stimulating effect on the expression of genes known to be involved in prostaglandin biosynthesis pathway, suggest its potential involvement in the regulation of preovulatory events in cattle.
Low EGR1 expression is associated with cardiac ischemia and systolic dysfunction.
Herein, we report that silencing of Egr-1 in the hippocampus by shRNA reduces tau phosphorylation, lowers amyloid-beta (Abeta (show APP ELISA Kits)) pathology, and improves cognition in the 3xTg-Alzheimer disease mouse model.
Egr-1 is a novel regulator of drebrin (show DBN1 ELISA Kits) expression, which is linked to changes in dendritic spine density
In the present study, we have investigated the contribution of element C to Krox20 (show EGR2 ELISA Kits) expression, as it was the only characterized initiator element with an activity in r3. Using a conditional knock-out mutation of element C, we show that, unexpectedly, this element is not necessary for Krox20 (show EGR2 ELISA Kits) initial expression in r3.
HAS2 (show HAS2 ELISA Kits)-produced hyaluronan is required for CD44V6 and TGFbetaRI co-localization and subsequent CD44V6/ERK1 (show MAPK3 ELISA Kits)/EGR1 signaling. These results demonstrate a novel positive-feedback loop that links the myofibroblast phenotype to TGFbeta1 (show TGFB1 ELISA Kits)-stimulated CD44V6/ERK (show EPHB2 ELISA Kits)/EGR1 signaling.
Egr1 expression is sensitive to mechanical signals in tendon cells.
age-related up-regulation of EGR1 promotes granulosa cell apoptosis in follicle atresia during ovarian aging.
data indicate that Egr-1 promotes Abeta (show APP ELISA Kits) synthesis via transcriptional activation of BACE-1 (show BACE ELISA Kits) and suggest that Egr-1 plays role in activation of BACE-1 (show BACE ELISA Kits) and acceleration of Abeta (show APP ELISA Kits) synthesis in AD brain.
EGR1, an early growth response factor, is a critical transcription factor that regulates the hepatic clock circuit.
EGR1(-/-) mouse embryonic fibroblasts demonstrated lower susceptibility to Venezuelan equine encephalitis virus-induced cell death than isogenic wild-type fibroblasts, indicating that EGR1 modulates proapoptotic pathways following virus infection.
egr1 colocalizes with tyrosine hydroxylase (show TH ELISA Kits) in the olfactory bulb throughout brain development.
successive induction of the transcription factors Runx3, Egr1 and Sox9b constitutes a regulatory cascade that controls expression of Follistatin A in pharyngeal endoderm, the latter modulating BMP signaling in developing cranial cartilage in zebrafish
The cDNA coding for zebrafish Egr1 was obtained and its expression pattern was examined during zebrafish embryogenesis using whole-mount in situ hybridization
Egr1 gene has important role in zebrafish embryonic oculogenesis. Lens and retina with egr1 gene deletion were primitive and lacked differentiation. Such arrested retinal and lenticular development in Egr1 morphants resulted in microphthalmos.
Gene therapy using in vivo transfection of an Egr-1 decoy ODN significantly inhibits proliferation of VSMC and intimal hyperplasia of vein grafts in a rabbit model.
Results show that EGR1 plays a key role in tendon formation, healing, and repair through BMP12 (show GDF7 ELISA Kits)/Smad1 (show SMAD1 ELISA Kits)/5/8 pathway.
Collectively, these results demonstrate that Egr-1 is expressed rapidly upon HSV-1 infection and that this novel induction could be due to the NFsmall ka, CyrillicB/CREB (show CREB1 ELISA Kits)-mediated transactivation.
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene.
early growth response protein 1(Egr-1, NGFI-A)
, early growth response protein 1 (egr-1)
, early growth response 1
, early growth response protein 1
, nerve growth factor-induced protein A
, transcription factor ETR103
, transcription factor Zif268
, zinc finger protein 225
, zinc finger protein Krox-24
, Krox-24 nuclear protein
, zinc finger protein ZENK
, zinc-finger transcriptional protein
, early growth response protein 1-A