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Disrupted in Schizophrenia 1 ELISA Kits (DISC1)
On are 3 Disrupted in Schizophrenia 1 (DISC1) ELISA Kits from 1 different suppliers available. Additionally we are shipping DISC1 Antibodies (190) and DISC1 Proteins (9) and many more products for this protein. A total of 214 DISC1 products are currently listed.
C1orf136, DISC1, SCZD9
list all ELISA KIts Gene Name GeneID UniProt
DISC1 27185 Q9NRI5
DISC1 244667 Q811T9
DISC1 307940 Q810H6

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More ELISA Kits for DISC1 Interaction Partners

Zebrafish Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. A Disc1 peptide binds to GSK3beta (show GSK3b ELISA Kits), and Disc1 directs early brain development and neurogenesis, by promoting beta-catenin (show CTNNB1 ELISA Kits)-mediated Wnt (show WNT2 ELISA Kits) signaling and inhibiting GSK3beta (show GSK3b ELISA Kits) activity.

  2. Disc1 and nrg1 (show NRG1 ELISA Kits) function in controlling development of oligodendrocytes and neurones from olig2 (show OLIG2 ELISA Kits)-expressing precursor cells.

  3. Disc1 functions in the transcriptional repression of foxd3 (show FOXD3 ELISA Kits) and sox10 (show SOX10 ELISA Kits), thus mediating cranial neural crest cell migration and differentiation.

Human Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. HTT (show HTT ELISA Kits) forms a ternary protein complex with the scaffolding protein DISC1 and cAMP-degrading phosphodiesterase 4 (PDE4 (show PDE4A ELISA Kits)) to regulate PDE4 (show PDE4A ELISA Kits) activity.

  2. This theme highlights the importance of understanding precisely how DISC1 can regulate intracellular trafficking, and suggests that a novel approach to the treatment of psychiatric disorders could be provided by targeting this protein and the trafficking machinery with which it interacts.

  3. Findings indicate that disrupted-in-schizophrenia 1 (DISC1) and close homolog of L1 (show CHL1 ELISA Kits) may engage in physical and functional interaction in neural development, supporting the notion that DISC1 regulates neurite outgrowth with a receptor belonging to the neural cell adhesion molecules.

  4. DISC1 increased the risk for late-onset Alzheimer's disease in northern Han Chinese population.

  5. Findings suggest that synapse-associated protein of 97-kDa molecular weight and disrupted in schizophrenia 1 contribute to maintaining Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling activity within a homeostatic range by regulating glycogen synthase kinase 3 beta (show GSK3b ELISA Kits) phosphorylation.

  6. DISC1 has distinctly folded regions, which are bisected by mental illness-related mutations

  7. These results should contribute to reveal DISC1 physiological function and potential pathogenic role in severe mental illnesses

  8. This population-based case-control study was carried out to determine whether polymorphisms in DISC1 and NRG1 (show NRG1 ELISA Kits) genes could be associated with schizophrenia in the Chinese population.

  9. This study demonstrated that the Increased density of DISC1-immunoreactive oligodendroglial cells in fronto-parietal white matter of patients with paranoid schizophrenia.

  10. The present findings, at least in part, provide some clues for further investigating the association of DISC1 variants with SCZ susceptibility

Mouse (Murine) Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. Co-disruption of DISC1 and NRG1 (show NRG1 ELISA Kits), indicative of epistasis, evoked an impairment in sociability and enhanced self-grooming, accompanied by changes in hypothalamic oxytocin/vasopressin (show AVP ELISA Kits) gene expression in a mouse schizophrenia model.

  2. the 100P mutation in Disc1 prevents expression of parvalbumin (show PVALB ELISA Kits) by a normally sized cohort of interneurons and altering Disc1 function in cortical excitatory neurons indirectly affects parvalbumin (show PVALB ELISA Kits) expression by cortical interneurons, perhaps as a result of altered functional input from the excitatory neurons.

  3. mutant DISC1 diminished the capacity of astrocytes to support dendritic and synaptic maturation in co-cultured neurons

  4. abnormality in hippocampal activity at the goal zone during the task may underlie the learning deficit observed in the DISC1 mutant mice.

  5. Missense mutation in DISC1 C-terminal coiled-coil has GSK3beta (show GSK3b ELISA Kits) signaling and sex-dependent behavioral effects in mice

  6. Systematic investigation suggests that DISC1 is present in several cellular compartments, including synapses, where it interacts with a wider molecular network to mediate cellular and synaptic function.

  7. Hypoxic preconditioning decreases NF-kappaB (show NFKB1 ELISA Kits) activity via Disc1.

  8. Results indicate that DISC1 attenuates Abeta (show APP ELISA Kits) generation and cognitive deficits of APP (show APP ELISA Kits)/PS1 (show PSEN1 ELISA Kits) transgenic mice through promoting lysosomal degradation of BACE1 (show BACE ELISA Kits)

  9. These results suggest that alteration of CB1R (show CNR1 ELISA Kits)-mediated signaling in DN-DISC1 mice may underlie susceptibility to detrimental effects of adolescent cannabis exposure on adult behaviors.

  10. These results uncover an unexpected role for DISC1 in normal beta-cell physiology and suggest that DISC1 dysregulation contributes to T2D independently of its importance for cognition.

DISC1 Antigen Profile

Antigen Summary

This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1\;11)(q42.1\;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative names and synonyms associated with DISC1

  • disrupted in schizophrenia 1 (disc1) Elisa Kit
  • disrupted in schizophrenia 1 (DISC1) Elisa Kit
  • disrupted in schizophrenia 1 (Disc1) Elisa Kit
  • C1orf136 Elisa Kit
  • DISC1 Elisa Kit
  • SCZD9 Elisa Kit

Protein level used designations for DISC1

disrupted in schizophrenia 1 protein , disrupted in schizophrenia 1 , disrupted in schizophrenia 1 homolog

407621 Danio rerio
719086 Macaca mulatta
742093 Pan troglodytes
100060246 Equus caballus
488970 Canis lupus familiaris
613555 Bos taurus
100156849 Sus scrofa
100356059 Oryctolagus cuniculus
100580606 Nomascus leucogenys
27185 Homo sapiens
244667 Mus musculus
307940 Rattus norvegicus
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