Browse our DSCAM Proteins (DSCAM)

Full name:
Down Syndrome Cell Adhesion Molecule Proteins (DSCAM)
On are 5 Down Syndrome Cell Adhesion Molecule (DSCAM) Proteins from 2 different suppliers available. Additionally we are shipping DSCAM Antibodies (48) and DSCAM Kits (4) and many more products for this protein. A total of 59 DSCAM products are currently listed.
43Bc, 4932410A21Rik, CG17800, CHD2-42, CHD2-52, CT39257, DmDscam, Dmel\\CG17800, Dm_2R:13612, dScam, Dscam-hv, Dscam1, FBgn0033159, GB15141, l(2)05518, l(2)43Bc, Neu1, p270
list all proteins Gene Name GeneID UniProt
DSCAM 1826 O60469
DSCAM 13508 Q9ERC8

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DSCAM Proteins (DSCAM) by Origin

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Zebrafish Down Syndrome Cell Adhesion Molecule (DSCAM) interaction partners

  1. Migrating cells utilize dscam to remodel the developing embryo

Fruit Fly (Drosophila melanogaster) Down Syndrome Cell Adhesion Molecule (DSCAM) interaction partners

  1. Dscam1, the role of which during heart development was previously unknown, is required for both normal migration of cardioblasts and luminal expansion.

  2. Sema1a and Dscam1 might play essential roles in the Drosophila DA1 (show TPM2 Proteins) ventral olfactory projection neurons morphogenesis.

  3. Studies suggest that the somatic mutually alternative splicing within a single gene may offer a simplified way of expressing a large Dscam repertoire.

  4. Protein production, crystallization and preliminary crystallographic analysis of the four N-terminal immunoglobulin domains of Dscam1 has been reported.

  5. Dysregulated Dscam binds to Abl through its cytoplasmic domain to enlarge presynaptic arbors in the Drosophila fragile X (show FMR1 Proteins) syndrome model.

  6. As thousands of Dscam isoforms are needed for the self-avoidance of the neuron, we propose that an increase in self-binding affinity provides the basis for the successful evolution of the arthropod brain

  7. Manipulation of the Dscam1 isoform pool in single neurons caused severe disruption of collateral formation of mechanosensory axons.

  8. The data of this study suggested that Dscam1 is required cell autonomously for normal adult motoneuron dendrite growth in Drosophila.

  9. Dscam1 splicing is probabilistic through the analysis of alternative exon 4 expression using splicing reporters; widespread probabilistic splicing supports a role for Dscam1 diversity in self-recognition throughout the developing nervous system.

  10. The found uncover a function of Dscam in presynaptic size control and provide insights into how dysregulated Dscam may contribute to the pathogenesis of neurological disorders.

Human Down Syndrome Cell Adhesion Molecule (DSCAM) interaction partners

  1. Our study did not repeatedly confirm the association of the rs2222973 or the rs11770843 SNP with adolescent idiopathic scoliosis in a Chinese Han population.

  2. The most significant was DSCAM, a neurological gene expressed widely in the developing brain and in the amygdala and hippocampus of the adult brain.

  3. DSCAM physically interacts with tubulin folding cofactor D (show TBCD Proteins).

  4. DSCAM as a Hirschsprung disease (HSCR (show EDNRB Proteins)) susceptibility locus, both in Down syndrome and HSCR (show EDNRB Proteins) isolated cases.

  5. Down syndrome cell adhesion molecule interacts with PRKAG1 (show PRKAG1 Proteins) subunit and plays an important role in netrin-1 (show NTN1 Proteins) induced neurite outgrowth.

  6. knockdown of DSCAM inhibits netrin-induced tyrosine phosphorylation of UNC5C (show Unc5c Proteins) and Fyn (show FYN Proteins) as well as the interaction of UNC5C (show Unc5c Proteins) with Fyn (show FYN Proteins). The double knockdown of both receptors abolishes the induction of Fyn (show FYN Proteins) tyrosine phosphorylation by netrin-1 (show NTN1 Proteins)

  7. The specificity of Drosophila Dscam is due to complementarity of variable residues in epitope I.

  8. Overall, our study found a significant association of IL-17RC (show IL17RC Proteins) gene polymorphisms with AIS (show AR Proteins) in a Chinese Han population, indicating IL-17RC (show IL17RC Proteins) gene may be as a susceptibility gene for AIS (show AR Proteins).

  9. Dscam may be involved in the generation and development of intractable epilepsy.

  10. functionally conserved with Drosophila Dscam[TM1 (show TPM2 Proteins)] isoforms

Mouse (Murine) Down Syndrome Cell Adhesion Molecule (DSCAM) interaction partners

  1. work presents the correlation between DSCAM gene overexpression and a dysregulation of the P21-activated kinases pathway.

  2. DSCAM mutation induces dystonic hypertonia and a disruption of locomotor gaits.

  3. DSCAM mutation reduces or abolishes spinal reflexes in both neonatal isolated spinal cords and adult mice.

  4. Results suggest that down syndrome cell adhesion molecule collaborates with deleted in colorectal cancer (show DCC Proteins) to regulate microtubule dynamics via direct binding to dynamic TUBB3 (show TUBB3 Proteins) in Netrin-1 (show NTN1 Proteins)-induced axon branching.

  5. Our results indicate an important role of DSCAM and DSCAML1 (show DSCAML1 Proteins) in the development of cortical neural network.

  6. DSCAM colocalizes in developmentally dynamic patterns with adhesion and synaptic proteins in the mouse retina.

  7. The findings of this study are as follows: (1) DSCAM is sufficient to drive cell death (2) dendrite avoidance defects in the Dscam loss-of-function retina do not reflect a role for DSCAM, and necessary and sufficient to target neurites.

  8. A novel splice isoform of Dscam causes defects in lamination of type 2 and type 6 cone bipolar cells in Dscam mutant mice.

  9. DSCAM contributes to pyramidal neuron morphogenesis by regulating dendrite arborization and spine formation during cortical circuit development

  10. somal clustering and fasciculation observed in the Dscam mutant retina are not unique to Dscam deficiency and are manifested distinctively by different retinal cell types.

DSCAM Protein Profile

Protein Summary

This gene is a member of the immunoglobulin superfamily of cell adhesion molecules (Ig-CAMs), and is involved in human central and peripheral nervous system development. This gene is a candidate for Down syndrome and congenital heart disease (DSCHD). A gene encoding a similar Ig-CAM protein is located on chromosome 11. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with DSCAM

  • Down syndrome cell adhesion molecule (DSCAM)
  • Down syndrome cell adhesion molecule (Dscam)
  • Down syndrome cell adhesion molecule (dscam)
  • Down syndrome cell adhesion molecule a (dscama)
  • down syndrome cell adhesion molecule (AaeL_AAEL010606)
  • down syndrome cell adhesion molecule (CpipJ_CPIJ006173)
  • 43Bc protein
  • 4932410A21Rik protein
  • CG17800 protein
  • CHD2-42 protein
  • CHD2-52 protein
  • CT39257 protein
  • DmDscam protein
  • Dmel\\CG17800 protein
  • Dm_2R:13612 protein
  • dScam protein
  • Dscam-hv protein
  • Dscam1 protein
  • FBgn0033159 protein
  • GB15141 protein
  • l(2)05518 protein
  • l(2)43Bc protein
  • Neu1 protein
  • p270 protein

Protein level used designations for DSCAM

Down syndrome cell adhesion molecule , CG17800-PA , CG17800-PAA , CG17800-PAB , CG17800-PAC , CG17800-PAD , CG17800-PAE , CG17800-PAF , CG17800-PAG , CG17800-PAH , CG17800-PAI , CG17800-PAJ , CG17800-PAK , CG17800-PAL , CG17800-PAM , CG17800-PAN , CG17800-PAO , CG17800-PAP , CG17800-PAQ , CG17800-PAR , CG17800-PAS , CG17800-PAT , CG17800-PAU , CG17800-PAV , CG17800-PAW , CG17800-PAX , CG17800-PAY , CG17800-PAZ , CG17800-PBA , CG17800-PBB , CG17800-PBC , CG17800-PBD , CG17800-PBE , CG17800-PBF , CG17800-PBG , CG17800-PBH , CG17800-PBI , CG17800-PBJ , CG17800-PBK , CG17800-PBL , CG17800-PBM , CG17800-PBN , CG17800-PBO , CG17800-PBP , CG17800-PBQ , CG17800-PBR , CG17800-PBS , CG17800-PBT , CG17800-PBU , CG17800-PBV , CG17800-PBW , CG17800-PBX , CG17800-PBY , CG17800-PBZ , CG17800-PC , CG17800-PCA , CG17800-PCB , CG17800-PCC , CG17800-PCD , CG17800-PD , CG17800-PE , CG17800-PF , CG17800-PG , CG17800-PH , CG17800-PI , CG17800-PJ , CG17800-PL , CG17800-PM , CG17800-PO , CG17800-PR , CG17800-PT , CG17800-PV , CG17800-PW , CG17800-PX , CG17800-PY , CG17800-PZ , Down's syndrome cell adhesion molecule , Dscam-PA , Dscam-PAA , Dscam-PAB , Dscam-PAC , Dscam-PAD , Dscam-PAE , Dscam-PAF , Dscam-PAG , Dscam-PAH , Dscam-PAI , Dscam-PAJ , Dscam-PAK , Dscam-PAL , Dscam-PAM , Dscam-PAN , Dscam-PAO , Dscam-PAP , Dscam-PAQ , Dscam-PAR , Dscam-PAS , Dscam-PAT , Dscam-PAU , Dscam-PAV , Dscam-PAW , Dscam-PAX , Dscam-PAY , Dscam-PAZ , Dscam-PBA , Dscam-PBB , Dscam-PBC , Dscam-PBD , Dscam-PBE , Dscam-PBF , Dscam-PBG , Dscam-PBH , Dscam-PBI , Dscam-PBJ , Dscam-PBK , Dscam-PBL , Dscam-PBM , Dscam-PBN , Dscam-PBO , Dscam-PBP , Dscam-PBQ , Dscam-PBR , Dscam-PBS , Dscam-PBT , Dscam-PBU , Dscam-PBV , Dscam-PBW , Dscam-PBX , Dscam-PBY , Dscam-PBZ , Dscam-PC , Dscam-PCA , Dscam-PCB , Dscam-PCC , Dscam-PCD , Dscam-PD , Dscam-PE , Dscam-PF , Dscam-PG , Dscam-PH , Dscam-PI , Dscam-PJ , Dscam-PL , Dscam-PM , Dscam-PO , Dscam-PR , Dscam-PT , Dscam-PV , Dscam-PW , Dscam-PX , Dscam-PY , Dscam-PZ , down syndrome cell adhesion molecule , down syndrome cell-adhesion molecule , drosophila down syndrome cell adhesion molecule , drosophila down syndrome cell adhesion molecule 1 , lethal(2)43Bc , down syndrome cell adhesion molecule-like , CHD2 , human CHD2-52 down syndrome cell adhesion molecule , Down syndrome cell adhesion molecule homolog

100058783 Equus caballus
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100553114 Anolis carolinensis
100604423 Nomascus leucogenys
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487768 Canis lupus familiaris
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