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Histone H3 (show HIST3H3 Proteins) arginine 2 dimethylation lysine 4 trimethylation, not simply H3lysine 4 trimethylation alone, is the mark of active promoters
Hepatic lipid accumulation alters global histone h3 (show HIST3H3 Proteins) lysine 9 and 4 trimethylation in the peroxisome proliferator-activated receptor alpha (show PPARA Proteins) network.
Increased levels of decondensed chromatin in both normal progenitor cells and cancer cells are associated with global loss of H3K27me3, which is linked to MYC (show MYC Proteins) overexpression.
histone H3 (show HIST3H3 Proteins) phosphorylation may be a molecular signature of the activated, retinoid-controlled mRARbeta2 gene promoter
differential regulation between gene expression and histone H3 (show HIST3H3 Proteins) acetylation in the variable regions of the TCRbeta locus
Rb effects permanent cell cycle exit in part by maintaining trimethylation of histone H3 (show HIST3H3 Proteins) lysine 27 (H3K27) on cell cycle genes.
Pygo2 (show PYGO2 Proteins) controls pattern of histone H3 (show HIST3H3 Proteins) hyperacetylation
Here we show that cAMP signaling regulates histone H3 (show HIST3H3 Proteins) phosphorylation in a cell cycle-dependent fashion, increasing it in quiescent cells but dramatically reducing it in cycling cells
Bmi1 (show BMI1 Proteins), which methylate H3K27, were present on the HSV-1 genome during latency.
The expression of OLC1 in the tumor tissues of lung adenocarcinoma is higher than that in squamous cell carcinoma.
Structural and biochemical studies reveal an unusually tight interaction between ULK3 (show ULK3 Proteins) and IST1, an ESCRT-III subunit required for cytokinetic abscission.
Crystal structures of three molecular complexes reveal that IST1 binds to the MIT domains of VPS4 and LIP5.
Overexpression of OLC1 promotes tumorigenesis of human esophageal squamous cell carcinoma.
Findings indicate that a high expression level of overexpressed in lung cancer 1 (OLC1) serves as a biomarker for poor prognosis for breast cancer, suggesting that OLC1 may be a potential target of antiangiogenic therapy for breast cancer.
the binding of ALG-2 (show PDCD6 Proteins) to IST1 is Ca(2 (show CA2 Proteins)+)-dependent
The results suggest that inclusion of IST1 into the ESCRT complex allows recruitment of spastin (show SPAST Proteins) to promote fission of recycling tubules from the endosome.
OLC1 over-expression is an important factor in epithelial ovarian carcinoma prognosis and can be a potential biomarker for ovarian carcinoma.
The interaction between CL7MIT and CHMP1B and between CL7MIT and IST1 became stronger when IST1 or CHMP1B was additionally coexpressed, suggesting formation of ternary complex of calpain-7, IST1 and CHMP1B.
These results demonstrate that cigarette smoke regulates OLC1 expression in lung cancer cells by compromising its ubiquitination and subsequent degradation through the ubiquitin E3 ligase APC (show APC Proteins).
This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
histone 1, H3f
, histone H3
, histone H3.2
, histone gene complex 1
, IST1 homolog
, overexpressed in lung cancer 1
, putative MAPK-activating protein PM28
, MAPK activating protein PM28