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Human ADA Protein expressed in Escherichia coli (E. coli) - ABIN667926
Daddona, Shewach, Kelley, Argos, Markham, Orkin: Human adenosine deaminase. cDNA and complete primary amino acid sequence. in The Journal of biological chemistry 1984
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The effects of increased adenosine in vivo by mutating the main Drosophila adenosine deaminase-related growth factor (ADGF-A), was studied.
findings show that a null mutation in ADGF-A leads to dramatically increased levels of adenosine & deoxyadenosine in the larval hemolymph; this increase leads to larval death associated with the disintegration of fat body & development of melanotic tumors
Crystal structure of CD26/dipeptidyl-peptidase IV (show DPP4 Proteins) in complex with adenosine deaminase
the transition-state structures of PfADA, HsADA, and bovine ADA (BtADA) solved using competitive kinetic isotope effects (KIE) and density functional calculations
This is the first report that an inhibitor molecule (EHNA) with a nucleoside framework binds to the open form of ADA and the first observation of conformational change of ADA in the crystalline state.
Data demonstrate that dipeptidyl peptidase II (show DPP7 Proteins) can form a complex with adenosine deaminase, but with one order of magnitude higher dissociation constant than that of DPPIV (show DPP4 Proteins).
Patients with tuberculous pleurisy who had high ADA values had a higher probability of manifesting pulmonary tuberculosis. High ADA values may help predict contagious pleuroparenchymal tuberculosis. The most common pulmonary involvement of tuberculous pleurisy showed a centrilobular nodular pattern.
our analysis shows that, mononuclear cells secretes ADA in response to leishmanial infection and the elevated serum ADA activity is associated with VL and PKDL (show PKD2L1 Proteins), and serum ADA activity can be used as prognostic marker to monitor the course of the treatment.
association between the occurrence of polycystic ovary syndrome with altered ADA activity and genetic distribution of G22A and A4223C polymorphisms of the ADA1 (show TADA1 Proteins) gene
High level of ADA is associated with obesity.
diagnostic value of serum adenosine deaminase (ADA) activity as a useful tool to differentiate HIV mono- and co-infection, was investigated.
Platelet aggregation and adenosine deaminase (ADA) activity were evaluated in pregnant women living with some disease conditions including hypertension, diabetes mellitus and human immunodeficiency virus infection.
Increase in serum ADA levels was observed in Oral Squamous Cell Carcinoma.
This study aimed to investigate the activities of purinergic system ecto (show TRIM33 Proteins)-enzymes present on the platelet surface as well as CD39 (show ENTPD1 Proteins) and CD73 expressions on platelets of sickle cell anemia treated patients.
Genetic variability within the ADA gene may influence adenosine concentration and in turn the immune response by lymphocytes in solid tumors.
We conclude that pleural ADA activity could be integrated in the diagnostic procedures of pTB (show PTBP1 Proteins) in low to medium tuberculosis prevalence settings.
Pulmonary alveolar proteinosis in adenosine deaminase-deficient mice
Dietary regulation of adenosine deaminase activity in stomach, small intestine and spleen of mice
Data indicate that untreated murine adenosine deaminase ADA(-/-) Tregs show alterations in the plasma membrane CD39 (show ENTPD1 Proteins)/CD73. ectonucleotidase machinery and limited suppressive activity via extracellular adenosine.
ADA is upregulated in NOD dendritic cells, which results in their exuberant and spontaneous activation, which triggers autoimmune T cell activation.
The catalytic mechanism of Mus (show TRPV6 Proteins) musculus adenosine deaminase (ADA) has been studied by quantum mechanics and two-layered ONIOM calculations
Adenosine deaminase is necessary but not sufficient to confer puromycin aminonucleoside sensitivity to podocytes.
adenosine deaminase deficient results in deoxy-ATP accumulation and leads to reduced thymic T cell production
Transactivation by a duodenum-specific enhancer requires functional GATA4 (show GATA4 Proteins) binding sites
ADA-deficient B cells exhibit a higher propensity to undergo B cell receptor-mediated apoptosis than their wild-type counterparts, and suggest a role for ADA in the survival of cells during antigen-dependent responses.
This study provides a basis for investigating the folding kinetics of murine ADA and folding mechanisms of (beta/alpha)8-barrel proteins using 19F NMR sepctroscopy.
after the immunotherapy, the rabbits showed an increase in the E-ADA activity when compared with control (78.62%), contributing for the change in the immune response.
This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia.
, adenosine deaminase
, adenosine deaminase-related growth factor A
, adenosine aminohydrolase