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Tcof1 loss-of-function resulted in fish showing phenotypes similar to those observed in TCS patients
In this study, the disordered feature of Nopp140 and the effect of CK2alpha on the structure of Nopp140 were examined using single-molecule fluorescence resonance energy transfer (smFRET) and electron paramagnetic resonance (EPR (show EREG Proteins)).
D120 and R195 of H5N1 influenza virus NS1 (show PTPN11 Proteins) were crucial for the binding to host NOLC1.
pRb2/p130 (show RBL2 Proteins) cytoplasmic delocalization can lead to cell cycle deregulation
our study demonstrated that DNA methylation (show HELLS Proteins) is a key mechanism of silenced NOLC1 expression in human hepatocellular carcinoma cells, and NOLC1 gene hypermethylation of the four CpG dinucleotides is a potential biomarker for hepatocellular carcinoma.
A Nopp140 fragment (residues 568-596) and inositol hexakisphosphate competitively bind to the catalytic subunit of CK2 (show CSNK2A1 Proteins) (CK2alpha), and phospho-Ser574 of Nopp140 significantly enhances its interaction with CK2alpha.
H5N1 viral NS1 (show PTPN11 Proteins) interacts with host NOLC1 protein.
NOPP140 is involved in a PKA signaling pathway that leads to agp activation
These data show that Nopp140 reversibly associates with snoRNPs in a phosphorylation-dependent manner, but this association has no effect on pseudouridylation of rRNA.
Hypoxia induces substantial p130 dephosphorylation and nuclear accumulation, leading to the formation of E2F4/p130 complexes and increased occupancy of E2F4 and p130 at the RAD51 and BRCA1 promoters.
hNopp140 serves as a negative regulator of CK2 (show CSNK2A1 Proteins) and InsP(6) stimulates the activity of CK2 (show CSNK2A1 Proteins) by blocking the interaction between hNopp140 and CK2 (show CSNK2A1 Proteins)
Enhanced NOLC1 promotes cell senescence and represses hepatocellular carcinoma cell proliferation by disturbing the organization of nucleolus.
UBF (show UBTF Proteins) and Nopp140 dynamic redistribution between the two-cell and blastocyst stages (time of implantation) is correlated with morphological and structural modifications that occur in embryonic nucleolar compartments.
interacts with protein phosphatase 1 and actin filaments\; involved in regulation of synaptic transmission
, nucleolar phosphoprotein
, nucleolar and coiled-body phosphoprotein 1
, 140 kDa nucleolar phosphoprotein
, HCV NS5A trans-regulated protein 13
, HCV NS5A-transactivated protein 13
, hepatitis C virus NS5A-transactivated protein 13
, nucleolar 130 kDa protein
, nucleolar and coiled-body phosphprotein 1
, nucleolar phosphoprotein p130
, nucleolar protein p130
, nucleolar phosphoprotein 140
, neurabin 2
, neural tissue-specific F-actin-binding protein II
, nuerabin 2