Browse our F2RL1 (F2RL1) ELISA Kits

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Coagulation Factor II (thrombin) Receptor-Like 1 ELISA Kits (F2RL1)
On are 39 Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) ELISA Kits from 9 different suppliers available. Additionally we are shipping F2RL1 Antibodies (43) and F2RL1 Proteins (7) and many more products for this protein. A total of 95 F2RL1 products are currently listed.
Gpcr11, GPR11, Par-2, Par2
list all ELISA KIts Gene Name GeneID UniProt
F2RL1 2150 P55085
F2RL1 14063 P55086
F2RL1 116677 Q63645

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Top referenced F2RL1 ELISA Kits

  1. Human F2RL1 ELISA Kit for Sandwich ELISA - ABIN415022 : Vasakova, Sterclova, Stranska, Mandakova, Skibova, Matej: Biomarkers of fibroproliferative healing in fibrosing idiopathic interstitial pneumonias. in The open respiratory medicine journal 2013 (PubMed)
    Show all 6 references for 415022

More ELISA Kits for F2RL1 Interaction Partners

Human Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) interaction partners

  1. TF-induced microvessel stabilization is regulated via PAR2-SMAD3 (show SMAD3 ELISA Kits) that is indispensable for the maintenance of vascular integrity.

  2. PAR-2- and PAR-1 (show MARK2 ELISA Kits)-mediated TNF-alpha (show TNF ELISA Kits) release from monocytes suggests that these unique protease receptors are involved in the pathogenesis of inflammation.

  3. Results indicate that chymotrypsin-like serine protease (show F2 ELISA Kits) enhances soluble fms-like tyrosine kinase 1 (show FLT1 ELISA Kits) production through protease-activated receptor-2 in trophoblast cells and thus plays an important additional role in preeclampsia pathogenesis.

  4. crystal structures of PAR2 in complex with two distinct antagonists and a blocking antibody

  5. PAR-2 plays an important role in the progression of ovarian clear cell carcinoma.

  6. Data suggest activation of PAR2 via FVIIA/TF signaling activates PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) signaling, inactivates GSK3b (show GSK3b ELISA Kits) signaling, leads to accumulation of beta-catenin (show CTNNB1 ELISA Kits), and promotes tumor cell migration/invasion. (PAR2 = protease-activated receptor 2; FVIIA = coagulation factor VIIa; TF = tissue factor/thromboplastin (show F3 ELISA Kits); PI3K (show PIK3CA ELISA Kits) = phosphatidylinositol 3-kinase; AKT (show AKT1 ELISA Kits) = proto-oncogene (show RAB1A ELISA Kits) protein c (show PROC ELISA Kits)-akt (show AKT1 ELISA Kits); GSK3b (show GSK3b ELISA Kits) = glycogen synthase kinase 3 beta (show GSK3b ELISA Kits))

  7. PAR2 modulation was sufficient to induce islet cell transdifferentiation in the absence of beta-cells.

  8. Studies provide increasing evidence that PAR2 plays a significant role in inflammatory diseases both in the periphery and in the CNS. There is a clear similarity between PAR2 expression and activation on cells of the immune system and those cell types that are proposed to play a role within the CNS, astrocytes and microglia. [review]

  9. Results show that PAR2 in hepatic stellate cells plays a crucial role in promoting hepatocellular carcinoma growth presumably by mediating migration and secretion of pro-angiogenic and pro-mitotic factors.

  10. Data highlight functional differences in proliferation and barrier integrity between dark keratinocytes and fair keratinocytes that are partly associated with their differential expression of PAR1 (show MARK2 ELISA Kits) and PAR2.

Mouse (Murine) Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) interaction partners

  1. PAR2 modulation was sufficient to induce islet cell transdifferentiation in the absence of beta-cells.

  2. Our results are suggestive that PAR2 inhibition may play a role in the treatment of diseases with increased inflammatory responses in renal systems

  3. PAR2/GSK3beta (show GSK3b ELISA Kits) is a novel pathway that plays a critical role in the regulation of stem/progenitor cell survival and proliferation in normal colon crypts and colon cancer.

  4. Enhanced FXa (show F10 ELISA Kits) and PAR2 exacerbate DN and that both are promising targets for preventing diabetic nephropathy.

  5. PAR2 is critically important in the pathogenesis of adenine-induced tubular injury

  6. The levels of miR (show MLXIP ELISA Kits)-223, miR (show MLXIP ELISA Kits)-339 and miR (show MLXIP ELISA Kits)-21, which are associated with platelet activation, were elevated in pooled mouse plasma exosomes before thrombosis and enriched in thrombin (show F2 ELISA Kits)-stimulated platelet-derived exosomes in vitro.

  7. Neutrophil elastase (show ELANE ELISA Kits) induced acute inflammation and pain in knee joints of mice. These changes are PAR2-dependent and appear to involve activation of a p44/42 MAPK (show MAPK1 ELISA Kits) pathway. Blocking neutrophil elastase (show ELANE ELISA Kits), PAR2 and p44/42 MAPK (show MAPK1 ELISA Kits) activity can reduce inflammation and pain, suggesting their utility as therapeutic targets.

  8. Reductions in astrogliosis, inflammation and neuromotor recovery observed in protease Activated Receptor 2 knockout mice after spinal cord injury suggests that this receptor and its agonists represent new drug targets to foster neuromotor recovery.

  9. Stimulation of PAR-2 activates Nf-kappaB (show NFKB1 ELISA Kits) signaling, resulting in RelA (show NFkBP65 ELISA Kits) nuclear translocation and enhanced expression of pro-inflammatory mRNAs in oral squamous cell carcinoma.

  10. Tryptase (show TPSAB1 ELISA Kits) and protease-activated receptor-2 stimulate scratching behavior in a murine model of ovalbumin (show OVA ELISA Kits)-induced atopic-like dermatitis

Cow (Bovine) Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1) interaction partners

  1. PAR1 (show F2R ELISA Kits) and PAR2 regulate endothelial NO synthase (show NOS ELISA Kits) phosphorylation and activity through G(12/13) and G(q), delineating the signaling pathways by which the proteases act on protease-activated receptors to modulate endothelial functions.

F2RL1 Antigen Profile

Antigen Summary

Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence.

Alternative names and synonyms associated with F2RL1

  • Proteinase-activated receptor 2 (par2) Elisa Kit
  • coagulation factor II (thrombin) receptor-like 1 (F2RL1) Elisa Kit
  • coagulation factor II (thrombin) receptor-like 1 (F2rl1) Elisa Kit
  • Gpcr11 Elisa Kit
  • GPR11 Elisa Kit
  • Par-2 Elisa Kit
  • Par2 Elisa Kit

Protein level used designations for F2RL1

Proteinase-activated receptor 2 , G-protein coupled receptor 11 , coagulation factor II receptor-like 1 , protease-activated receptor 2 , proteinase-activated receptor 2 , thrombin receptor-like 1 , Protease-activated receptor-2 , proteinase-activated receptor-2 , Proteinase-activated receptor-2 G protein-coupled receptor 11 , Proteinase-activated receptor-2, G protein-coupled receptor 11 , PAR-2

100195488 Salmo salar
2150 Homo sapiens
14063 Mus musculus
116677 Rattus norvegicus
526525 Bos taurus
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