Browse our FCGRT Proteins (FCGRT)

Full name:
Fc Fragment of IgG, Receptor, Transporter, alpha Proteins (FCGRT)
On are 24 Fc Fragment of IgG, Receptor, Transporter, alpha (FCGRT) Proteins from 7 different suppliers available. Additionally we are shipping FCGRT Antibodies (86) and FCGRT Kits (15) and many more products for this protein. A total of 129 FCGRT products are currently listed.
alpha-chain, FcRn
list all proteins Gene Name GeneID UniProt
FCGRT 2217 P55899
FCGRT 29558 P13599
FCGRT 14132 Q61559

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FCGRT Proteins (FCGRT) by Origin

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Top referenced FCGRT Proteins

  1. Human FCGRT Protein expressed in HEK-293 Cells - ABIN2181085 : Goebl, Babbey, Datta-Mannan, Witcher, Wroblewski, Dunn: Neonatal Fc receptor mediates internalization of Fc in transfected human endothelial cells. in Molecular biology of the cell 2008 (PubMed)
    Show all 2 references for 2181085

  2. Rat (Rattus) FCGRT Protein expressed in HEK-293 Cells - ABIN2181083 : Gorevic, Munoz, Casey, DiRaimondo, Stone, Prelli, Rodrigues, Poulik, Frangione: Polymerization of intact beta 2-microglobulin in tissue causes amyloidosis in patients on chronic hemodialysis. in Proceedings of the National Academy of Sciences of the United States of America 1986 (PubMed)
    Show all 2 references for 2181083

  3. Human FCGRT Protein expressed in Wheat germ - ABIN1353903 : Deissler, Lang, Lang: Internalization of bevacizumab by retinal endothelial cells and its intracellular fate: Evidence for an involvement of the neonatal Fc receptor. in Experimental eye research 2015 (PubMed)

  4. Human FCGRT Protein expressed in HEK-293 Cells - ABIN2720989 : Fan, Neubert: Quantitative Analysis of Human Neonatal Fc Receptor (FcRn) Tissue Expression in Transgenic Mice by Online Peptide Immuno-Affinity LC-HRMS. in Analytical chemistry 2016 (PubMed)

More Proteins for FCGRT Interaction Partners

Human Fc Fragment of IgG, Receptor, Transporter, alpha (FCGRT) interaction partners

  1. Data suggest that, unlike albumin (show ALB Proteins) with low FcRn-binding affinity, albumin (show ALB Proteins) with high FcRn-binding affinity (due to genetic variation/genetic engineering) is directed less to lysosomes and more to endosomes, suggestive of FcRn-directed albumin (show ALB Proteins) salvage from lysosomal degradation. (FcRn = neonatal Fc receptor)

  2. the localization of FcRn alpha-chain in fixed nasal tissue, was studied.

  3. FcRn is involved in transport of aflibercept through REC in vitro.

  4. this study shows that FcRn may be associated with the transport and metabolism of IgG in thyrocytes and that transport is independent of IgG type, and that FcRn may be involved in Hashimoto's thyroiditis pathogenesis

  5. This review summarizes the main findings on Fc Receptor neonatal biology, function and distribution throughout different tissues.

  6. The results suggest that regardless of hyperglycemia degree, it decreases FcRn expression in placenta and blood cells and compromises the production and transfer of antibodies from maternal blood to newborns.

  7. Data indicate improved pharmacokinetics through enhanced neonatal Fc receptor (FcRn) interactions were apparent for a complementarity-determining region (CDR (show RUNX1T1 Proteins)) charge-patch normalized monoclonal antibody (mAb) which was affected by non-specific clearance.

  8. analysis of binding motifs in the hFCGRT promoter that interact with their corresponding (Sp1 (show PSG1 Proteins), Sp2, Sp3, c-Fos, c-Jun (show JUN Proteins), YY1 (show YY1 Proteins), and C/EBPbeta (show CEBPB Proteins) or C/EBPdelta (show CEBPD Proteins)) transcription factors (TFs) suggests their involvement in regulation of human FCGRT gene expression

  9. These data indicate that human FcRn facilitates the transepithelial transport of IgE in the form of IgG anti-IgE/IgE ICs.

  10. none of the three functional polymorphisms in FcgammaR genes explored here, the FCGR3A (show CD16 PLURAL_@40859@) F158V and FCGR2B (show FCGR2B PLURAL_@40859@) I232T nsSNPs and the VNTR in FCGRT, showed an association with the response to TNFi in patients with rheumatoid arthritis

Cow (Bovine) Fc Fragment of IgG, Receptor, Transporter, alpha (FCGRT) interaction partners

  1. The transport of IgGs in the mammary gland, by FcRn, was investigated.

  2. The present data support the notion that FcRn might be involved in the transfer of maternal immunoglobulins and in the local defense mechanism of the mammary gland.

  3. FcRn alpha chain gene has acquired several repetitive sequences in its 5'-flanking region, including multiple SINE and LINE elements. Potential binding sites for transcription factors within the 5'-flanking sequence were identified

  4. haplotype could also weaken the IgG-FcRn affinity, which may increase the IgG concentration in the milk.

Mouse (Murine) Fc Fragment of IgG, Receptor, Transporter, alpha (FCGRT) interaction partners

  1. Preproinsulin (show INS Proteins) fused to Fc administered to pregnant mice efficiently accumulated in fetuses through the placental neonatal Fc receptor and protected them from subsequent diabetes development.

  2. The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.

  3. Characterization and screening of IgG binding to the neonatal Fc receptor.

  4. Fc receptor promotes formation of subepithelial immune complexes and subsequent glomerular pathology leading to proteinuria

  5. Abundant intracellular IgG in enterocytes and endoderm lacking FcRn.

  6. Extending serum half-life of albumin (show ALB Proteins) by engineering neonatal Fc receptor (FcRn) binding.

  7. FcRn thus has a primary role within mucosal tissues in activating local immune responses that are critical for priming efficient anti-tumor immunosurveillance

  8. Neonatal Fc receptor for IgG uptake mediates intestinal absorption of IgG(1) anti-IgE/IgE immune complexes.

  9. Nck (show NCK1 Proteins) and Cdc42 (show CDC42 Proteins) co-operate to recruit N-WASP (show WASL Proteins) to promote FcgammaR-mediated phagocytosis.

  10. AMG (show AMELX Proteins) 386 clearance in FcRn-knockout mice was 18-fold faster at the 3-mg/kg dose.

FCGRT Protein Profile

Protein Summary

This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with FCGRT

  • Fc fragment of IgG, receptor, transporter, alpha (FCGRT)
  • Fc fragment of IgG, receptor, transporter, alpha (Fcgrt)
  • Fc receptor, IgG, alpha chain transporter (Fcgrt)
  • alpha-chain protein
  • FcRn protein

Protein level used designations for FCGRT

FcRn alpha chain , IgG Fc fragment receptor transporter alpha chain , IgG receptor FcRn large subunit p51 , immunoglobulin receptor, intestinal, heavy chain , major histocompatibility complex class I-like Fc receptor , neonatal Fc receptor , neonatal Fc-receptor for Ig , IgG transcytosis and recycling receptor , MHC class I-related Fc gamma receptor , igG receptor FcRn large subunit p51 , neonatal Fc receptor FcRn , Fc receptor , Fc fragment immunoglobulin G receptor , Fc receptor, IgG, alpha chain transporter , igG Fc fragment receptor transporter alpha chain

2217 Homo sapiens
476414 Canis lupus familiaris
397399 Sus scrofa
338062 Bos taurus
29558 Rattus norvegicus
14132 Mus musculus
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