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We show that the expression of LAG3 is highly induced in the lungs and particularly in the granulomatous lesions of macaques experimentally infected with mycobacterium tuberculosis.
thi study shows that LAG-3 directly modulates the size of the T cell response and support the use of LAG-3 blockade regimens to enhance CD8 (show CD8A ELISA Kits)+ T cell responses
Study suggests that expression of the inhibitory receptors PD-1 (show PDCD1 ELISA Kits) and LAG-3 on CD4 (show CD4 ELISA Kits)(+) T cells and their reduced IL-2 (show IL2 ELISA Kits) production are common characteristic features of Plasmodium infection.
An IL-27 (show IL27 ELISA Kits)/Lag3 axis enhances Foxp3 (show FOXP3 ELISA Kits)+ regulatory T cell-suppressive function and therapeutic efficacy.
LAG3 and PD1 (show PDCD1 ELISA Kits) co-inhibitory molecules have roles in collaborating to limit CD8 (show CD8A ELISA Kits)+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model
Poxvirus-Based Active Immunotherapy with PD-1 (show PDCD1 ELISA Kits) and LAG-3 Dual Immune Checkpoint Inhibition Overcomes Compensatory Immune Regulation, Yielding Complete Tumor Regression in Mice.
Lymphatic endothelial cells (LECs) serve as an antigen reservoir for CD4 (show CD4 ELISA Kits) T-cell tolerance, and MHC-II molecules on LECs are used to induce CD8 (show CD8A ELISA Kits) T-cell tolerance via LAG-3.
LAG-3 expression on Tconv cells makes them more susceptible to Treg based suppression, and also regulates the development of a TH1 (show HAND1 ELISA Kits) T-cell response.
LAG-3 exerts an important regulatory effect on autoimmunity.
Lag-3 is an important regulatory molecule involved in alloreactive T cell proliferation and activation after bone marrow transplantation.
these results define a strong synergy between the PD-1 (show PDCD1 ELISA Kits) and LAG-3 inhibitory pathways in tolerance to both self and tumor antigens.
Overexpression of lymphocyte activation gene-3 inhibits regulatory T cell responses in osteoarthritis
Egr2 (show EGR2 ELISA Kits)-driven cell surface proteins LAG-3 and 4-1BB (show TNFRSF9 ELISA Kits) can identify dysfunctional tumor antigen-specific CD8 (show CD8A ELISA Kits)(+) TIL (show TLR1 ELISA Kits).
our data indicate that the evaluation of stromal TILs remains the most reliable immune prognostic marker in TNBC, and support the clinical evaluation of anti-PD-1 (show PDCD1 ELISA Kits)/PD-L1 (show CD274 ELISA Kits) and anti-LAG-3 in a subset of patients with TNBC who have concurrent expression of both checkpoint receptors.
this review provides the translational rationale for targeting LAG3, as well as historical and current state of clinical trials utilizing LAG3 cancer immunomodulators
this study shows that LAG3 expressed on myeloid leukaemia cells possess the capacity to facilitate functional exhaustion in T helper cells
epigenetic modification on LAG-3 increased LAG-3(+) T cells and its immune regulatory roles in chronic osteomyelitis progression
Immune checkpoint proteins are co-inhibitory factors that can diminish the antigen-specific immune responses by attenuating the regulatory role of cytotoxic T-lymphocyte-associated protein 4 (show CTLA4 ELISA Kits), programmed cell death-1 (show PDCD1 ELISA Kits), lymphocyte-activation gene 3, and T-cell immunoglobulin mucin-3 (show HAVCR2 ELISA Kits).
LAG3 binds alpha-synuclein (show SNCA ELISA Kits) preformed fibrils (PFF) with high affinity (dissociation constant = 77 nanomolar), whereas the alpha-syn monomer exhibited minimal binding. alpha-Syn-biotin PFF binding to LAG3 initiated alpha-syn PFF endocytosis, transmission, and toxicity.
LAG-3 is highly expressed in peripheral blood CD8 (show CD8A ELISA Kits)+ T cells in chronic HBV-infected patients.
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4.
lymphocyte-activation gene 3
, lymphocyte-activation protein 3
, lymphocyte-activation protein 3-like
, lymphocyte activation gene 3 protein-like
, lymphocyte activation gene 3 protein
, lymphocyte activation gene 3