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Human mucosal-associated invariant T cells possess capacity for B cell help via MR1-mediated immunoglobulins production.
Early endosomal TLR9 (show TLR9 Proteins) activation is important for MR1-mediated bacterial antigen presentation in B cells.
Polymorphism in MR1 gene is associated with susceptibility to tuberculosis.
we have shown that MR1-mediated MAIT cell activation is tightly regulated at several levels. Efficient MR1-mediated MAIT cell activation requires both intact bacteria to access an acidified endolysomal compartment and activation of the APC (show APC Proteins) through NF-kappaB (show NFKB1 Proteins) or interferon (show IFNA Proteins) signaling pathways.
results suggest that high expression of MR-1 is involved in hepatocellular carcinoma progression
Data show that the major histocompatibility complex, class I-related protein (MR1) antigen presentation is characterized by a rapid 'off-on-off' mechanism that is strictly dependent on antigen availability.
endosome-mediated trafficking of MR1 allows for selective sampling of the intracellular environment
Studies indicate that the antigen-presenting molecules CD1 (show CD1A Proteins) and MHC class I-related protein (MR1) display lipids and small molecules to T cells.
Data indicate that high expression of CD26 (show DPP4 Proteins) ia a specific markers to define major histocompatibility complex, class I-like sequence protein MR1-restricted mucosa-associated invariant T (MAIT) cells.
Mucosal-associated invariant T cell adaptation was a direct consequence of exposure to various exogenous MR1-restricted epitopes.
MR1 tetramers allow precise phenotypic characterization of human and mouse mucosal-associated invariant T cells.
differential contribution of particular amino acids to the MAIT TCR-MR1 interaction based upon the presence of bacteria
Data suggest that constitutive expression of MR1 may be detrimental for maintenance of immune homeostasis in the gut (show GUSB Proteins) and/or detection of pathogenic bacteria in mucosal tissues.
fact that MR1 seems mainly intracellular might offer clues as to the process, given the precedence in other class I molecules
Gene silencing of myofibrillogenesis regulator-1 by adenovirus-delivered small interfering RNA suppresses cardiac hypertrophy induced by angiotensin II in mice.
MR1 protein can associate with beta(2)-microglobulin (show B2M Proteins)
Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1
Analysis of murine MR1 expressed in a murine cell line reveals that MR1 associates with the peptide-loading complex, indicating that MR1 uses the same cellular assembly machinery as do classical class I molecules.
MR1 has an antigen presentation function
HA peptides are expressed by EGCs and recognized by CD8 T cells that express a T-cell receptor (TCR) specific for Kd:HA512-520 (CL4) or CD4 T cells that express a TCR specific for IEd:HA107-119 (6.5), respectively.
non-MHC-linked class I-related gene
MHC Rfp-Y class I alpha chain
, MHC class I-related protein
, major histocompatibility complex class I-related gene protein
, major histocompatibility complex class I-related protein variant 550
, major histocompatibility complex, class I-related
, Major histocompatibility complex class I-related gene protein
, MHC class I-like antigen MR-1
, MHC class I-related gene protein
, MHC class-I related-gene protein
, class I histocompatibility antigen-like protein
, major histocompatibility complex, class I-like sequence
, MCH class I
, histocompatibility-2 complex class 1-like sequence
, MHC class I-like sequence
, MHC class I related protein, MR1B1 isoform