Browse our WWTR1 Proteins (WWTR1)

Full name:
WW Domain Containing Transcription Regulator 1 Proteins (WWTR1)
On www.antibodies-online.com are 5 WW Domain Containing Transcription Regulator 1 (WWTR1) Proteins from 3 different suppliers available. Additionally we are shipping WWTR1 Antibodies (53) and WWTR1 Kits (2) and many more products for this protein. A total of 64 WWTR1 products are currently listed.
Synonyms:
2310058J06Rik, 2610021I22Rik, C78399, Taz, WWTR1
list all proteins Gene Name GeneID UniProt
WWTR1 25937 Q9GZV5
Mouse WWTR1 WWTR1 97064 Q9EPK5
Rat WWTR1 WWTR1 295062  

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WWTR1 Proteins (WWTR1) by Origin

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More Proteins for WWTR1 Interaction Partners

Zebrafish WW Domain Containing Transcription Regulator 1 (WWTR1) interaction partners

  1. Yap (show YAP1 Proteins)/Taz (show TAZ Proteins)-Tead activity is necessary and sufficient for optic vesicle progenitors to adopt retinal pigment epithelium identity in zebrafish.

  2. Taz (show TAZ Proteins) is required in the anteroposterior patterning of the pronephric progenitor domain in the intermediate mesoderm, acting in part by regulating retinoic acid signaling in the pronephric progenitor field in the intermediate mesoderm.

  3. Taz (show TAZ Proteins)-depleted larvae displayed patterning defects in ventral cranial vessels that correlate with lateral displacement of thyroid follicles

  4. When transcriptional coactivators Yap (show YAP1 Proteins) and Taz (show TAZ Proteins) were restricted from interacting with Tead transcription factors through expression of a dominant negative transgene, cardiac precursors failed to migrate completely to the midline.

  5. TAZ (show TAZ Proteins) has a critical role in osteoblast differentiation in vivo

Human WW Domain Containing Transcription Regulator 1 (WWTR1) interaction partners

  1. results provide evidence that TAZ (show TAZ Proteins) and miR (show MLXIP Proteins)-135b engage in a positive feedback loop to regulate epithelial-mesenchymal transition and metastasis in osteosarcoma, and suggest that both factors can be therapeutic targets for osteosarcoma treatment.

  2. extracellular matrix stiffening sustains vascular cell growth and migration through YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins)-dependent glutaminolysis and anaplerosis

  3. a stiffness-dependent YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins)-mediated positive feedback loop that drives remodeling phenotypes in pulmonary artery smooth muscle cells via reduced COX-2 and prostaglandin activity.

  4. ETAR (show EDNRA Proteins) stimulation acted via downstream G-protein Galphaq (show GNAQ Proteins)/11 and Rho GTPase (show RACGAP1 Proteins) to suppress the Hippo pathway, thus leading to YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) activation, which was required for ETAR (show EDNRA Proteins)-induced tumorigenesis. Overall, these results indicate a critical role of the YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) axis in ETAR (show EDNRA Proteins) signaling

  5. Various studies show that in human cancers, the Hippo pathway is frequently deregulated allowing YAP1 (show YAP1 Proteins) and TAZ (show TAZ Proteins) to escape the inhibition by the Hippo pathway. The upregulation of YAP1 (show YAP1 Proteins) and TAZ (show TAZ Proteins) induces epithelial-mesenchymal transition and increases drug resistance in cancer cells. TAZ (show TAZ Proteins) is implicated in cancer stemness.[review]

  6. Results demonstrate a pivotal role for TAZ (show TAZ Proteins) in regulating the differentiation of Treg cells and TH17 cells.

  7. the transcription regulators YAP (show YAP1 Proteins) and TAZ (show TAZ Proteins) localise to the nucleus in the basal layer of skin and are elevated upon wound healing.

  8. In colorectal carcinoma TIAM1 (show TIAM1 Proteins) suppresses tumor progression by regulating YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) activity.

  9. Growing evidence suggests that transcriptional effectors of the Hippo pathway, YAP (show YAP1 Proteins) and TAZ (show TAZ Proteins), promote resistance to various anti-cancer therapies, including cytotoxic chemotherapy, molecular targeted therapy, and radiation therapy. [review]

  10. SGK1 promotes YAP/TAZ transcriptional activity. SGK1 enhances YAP/TAZ activity by upregulating YAP/TAZ. SGK1 is a transcriptional target of YAP. SGK1 stabilizes TAZ by inhibiting GSK3beta.

Mouse (Murine) WW Domain Containing Transcription Regulator 1 (WWTR1) interaction partners

  1. Yap (show YAP1 Proteins) and Taz (show TAZ Proteins) leads to impaired epicardial epithelial-to-mesenchymal transition (EMT (show ITK Proteins)) and a reduction in epicardial cell proliferation and differentiation into coronary endothelial cells.

  2. This study identifies YAP/TAZ as central mediators of VEGF signaling

  3. TAZ is required for TGFbeta induction of smooth muscle genes and is also required for the differentiated VSMC phenotype; synergy between TAZ and SRF, and TAZ and Myocardin (MyoC856), in regulating smooth muscle gene activation was observed in primary aortic vascular smooth muscle cells.

  4. Results demonstrate a pivotal role for TAZ (show TAZ Proteins) in regulating the differentiation of Treg cells and TH17 cells.

  5. ABL (show ABL1 Proteins) potentiated the assembly and activation of the RUNX2 (show RUNX2 Proteins)-TAZ (show TAZ Proteins) master transcription factor complex that is required for osteoblastogenesis, while antagonizing PPARgamma (show PPARG Proteins)-mediated adipogenesis.

  6. the transcription regulators YAP (show YAP1 Proteins) and TAZ (show TAZ Proteins) localise to the nucleus in the basal layer of skin and are elevated upon wound healing.

  7. These results suggest that vinculin (show VCL Proteins) promotes the nuclear localization of transcription factor TAZ (show TAZ Proteins) to inhibit the adipocyte differentiation on rigid extracellular matrix.

  8. TAZ (show TAZ Proteins) represents a previously unrecognized factor that contributes to the critical process of steatosis-to-Nonalcoholic Steatohepatitis progression.

  9. both Snail (show SNAI1 Proteins) and Slug (show SNAI2 Proteins) are able to form binary complexes with either YAP (show YAP1 Proteins) or TAZ (show TAZ Proteins) that, together, control YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) transcriptional activity and function throughout mouse development.

  10. results demonstrate that skeletal stem/stromal cell mobilize Snail (show SNAI1 Proteins)/Slug (show SNAI2 Proteins)-YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) complexes to control stem cell function

WWTR1 Protein Profile

Protein Summary

This gene encodes a binding protein of the 14-3-3 family of proteins that regulate cell cycle progression, differentiation and apoptosis. The encoded protein is a transcriptional co-activator that binds to the PPXY motif present on transcription factors. The gene product contains a WW domain and, in the C-terminus, a conserved PDZ-binding motif. This gene is distinct from the gene encoding tafazzin. Both genes share the gene symbol Taz. Multiple transcript variants encoding different isoforms have been described.

Alternative names and synonyms associated with WWTR1

  • WW domain containing transcription regulator 1 (wwtr1)
  • WW domain containing transcription regulator 1 (WWTR1)
  • WW domain containing transcription regulator 1 (Wwtr1)
  • 2310058J06Rik protein
  • 2610021I22Rik protein
  • C78399 protein
  • Taz protein
  • WWTR1 protein

Protein level used designations for WWTR1

WW domain containing transcription regulator 1 , WW domain-containing transcription regulator protein 1 , taz , WW domain-containing transcription regulator protein 1-like , transcriptional co-activator with PDZ-binding motif , transcriptional coactivator with PDZ-binding motif , transcriptional coactivator with PDZ binding motif , transcriptional co-activator with PDZ-binding motif (TA)Z , transcriptional co-activator with PDZ-binding motif (TAZ)

GENE ID SPECIES
496155 Xenopus laevis
568008 Danio rerio
100050661 Equus caballus
100401831 Callithrix jacchus
100437619 Pongo abelii
100493170 Xenopus (Silurana) tropicalis
100522573 Sus scrofa
100592028 Nomascus leucogenys
25937 Homo sapiens
609743 Canis lupus familiaris
614786 Bos taurus
97064 Mus musculus
295062 Rattus norvegicus
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